Fatty acids contain from 4 to 22 carbon atoms. They can be saturated, having no double bonds in the carbon chain, mono-unsaturated with one double bond in the chain, or polyunsaturated with several double bonds in the fatty acid.
In nature, triglycerides occur linked (esterified) to glycerol and hence are called glycerides. If solid they are called fats, if liquid they are called oils. One fatty acid combined (esterified) with glycerol is a monoglyceride, two combined is a diglyceride, and three attached to the glycerol backbone (the most possible) is a triglyceride.
Saturated fat (e.g. palmitic and stearic) exclusively fit in the 1 and 3 positions whereas unsaturated fatty acids can distribute randomly among the three positions on the glycerol backbone. A common configuration is thus a saturated fat in positions 1 and 3 and an unsaturated fatty acid in position 2. (Fig. 3)
[ Structure of a Triglyceride Image ] http://www.wysong.net/articles/lipid/figures//figure3.jpg
Fatty acids containing fewer than 16 carbon atoms, and saturated fatty acids, are largely oxidized to provide energy. Those containing 16 to 22 carbon atoms can also be oxidized for energy, but in addition can be incorporated into cell membranes, regulate metabolism after conversion to eicosanoids (prostaglandins, thromboxanes, leukotrienes, lipoxins, and various other hydroxy analogs discussed later) changed to other fatty acids, or stored in fat (adipose) tissues.
NOMENCLATURE Abbreviated notations simplify fatty acid nomenclature. In the case of linoleic acid (abbreviated LA; notation 18:2w6). The 18 means the molecule has 18 carbon atoms, the 2 means that there are two double bonds in the molecule and the w6 means the first double bond begins with the sixth carbon atom counting from the methyl (CH3), omega (w) end of the carbon chain. (In many publications omega is designated as a small case "n" instead of" w.") The other end of the chain, the carboxylic acid end, is termed the delta (?) end. (Fig. 4)
[ Linoleic and Linolenic Acid Structure and Nomenclature Image ] http://www.wysong.net/articles/lipid/figures/figure4.jpg
The double bonds in the nutritionally important fatty acids are separated by methylene groups (CH2). Hence, the second double bond in LA must begin with the ninth carbon atom. Common fatty acids are detailed in Figure 5.
[Nomenclature and Structure of Common Fatty Acids Image ] http://www.wysong.net/articles/lipid/figures/figure5.jpg
PHOSPHOLIPIDS Fatty acids with 16 and l8-carbon chains can participate in the manufacture of phospholipids which are the main structural components of cell membranes. Phospholipids are similar to triglycerides in that fatty acid molecules are attached to a glycerol molecule, a three carbon alcohol (or, less commonly, sphingosine, a more complex amino alcohol). In triglycerides, all three esterifiable positions on a glycerol molecule are occupied by a fatty acid. In a phospholipids, only two are so occupied and the third is esterified to phosphoric acid which may have in turn other compounds attached to it such as choline, serine, glycerol, inositol or ethanolamine. Lecithin, the best known phospholipids, has choline attached to the phosphate and is thus termed phosphatidylcholine. If phosphoric acid alone is attached, the compound is called a phosphotidate. Many molecular variations are also possible by mixing various fatty acids on the glycerol backbone. (Fig. 6)
[Structure of Phospholipids Image ] http://www.wysong.net/articles/lipid/figures/figure6.jpg
ISOMERS Figure 7 demonstrates the biochemically important cis- and trans- forms of fatty acids. Notice in the cis- form the hydrogen atoms on the carbons adjacent to the double bond are on the same side of the molecule. The repulsive forces between these "crowded" hydrogen atoms cause unsaturated fatty acids to assume particular non-linear shapes which play an important role in lipid membrane configuration, fluidity, and in biochemical reactions involving enzymes.
In the trans- form of fatty acids, the hydrogen atoms are on opposite sides of the molecule and their repulsive forces cancel each other, and thus the molecule is not bent. Although the trans- form is more stable, its chemical properties and biological functions are altered. (Figs. 7 and 8)
BIOLOGICAL MEMBRANES A biological (plasma) membrane surrounds all cells within tissue as well as the organelles lying within the cytoplasm. To help visualize size, if we were the size of bacteria, a cell would be the size of a large auditorium. (In true size, one billion cells fit in one cubic inch.) This cell "auditorium" is housed by a skin only two molecules thick. The various drawings of biochemicals depicted in these pages would therefore be as they would appear from our size as a bacteria, or as a bacteria sized person would see them through a magnifying glass.
The membrane is not a static sac, but rather a complex of chemicals with gates and pumps to control chemical and ionic balances, receptors for stimuli and signal generators. It is made up primarily of phospholipids, protein, glycolipids and cholesterol, all of which of course come directly from food or are synthesized in situ by components of food after they have been broken down by digestion.
Membrane lipids are amphipathic in that they contain both a hydrophilic polar end and a hydrophobic non-polar end. Phospholipids orient themselves into a bilayer sheet in membranes with the hydrophilic ends pointed to the outside and the hydrophobic hydrocarbon tails pointing to the inside. These properties make salts of fatty acids an important functional component of soaps since their fat soluble hydrophobic ends attract "fatty dirt" and their water soluble hydrophilic ends can attract "watery dirt."
The neck of a fatty acid is located next to the delta carboxyl end and is stiff. The tail portion next to the omega end, if containing cis- double bonds, is highly active, oscillating at a million vibrations per second. (Figs. 8 and 9)
Lipids, and some proteins within membranes, are also in constant lateral motion. In a bacterium, a single phospholipid will travel from one end to the other in one second. Thus membranes are in effect two-dimensional solutions of an array of oriented molecules. Although membranes are considered lipid bilayers, almost 50% of the membrane is composed of protein which serves many functional roles. The sugar residues of glycolipids (sphingosine + fatty acid + sugar, such as sphingomyelin) and glycoproteins (sugars attached to membrane proteins) are found protruding on the outer surface of membranes. Cholesterol, as well as the length of fatty acid tails and their degree of saturation, affects membrane fluidity. Cholesterol sandwiched between membrane fatty acids prevents their crystallization. (Fig. 10)
The specific spatial configuration and electronegative discontinuity of essential fatty acids pennit linkage with sulfhydral protein groups in membranes to form pi electron quantum mechanical membrane potentials that affect the transport of oxygen into tissues. Also, it is on the lipid membranes of mitochondria that cellular respiration occurs and energy is packaged for use throughout the body. Thus dietary fatty acids, which ultimately build all membranes, affect the burning of nutrient fuels -- the most fundamental of life's energetic properties.
Classic artistic renderings of biological membranes are overly simplistic and create an impression of static barriers. Similarly a photograph of a rocket ship streaking toward space says nothing about its actual movement, speed or the hubbub of activity occurring inside of it.
The real biological membrane, containing millions of fatty acid tails vibrating at millions of times per second, with deletions and substitutions in constant progress and biochemical doors opening and closing selectively permitting the passage of food and waste, is a dynamic, an action more than a structure and literally beyond comprehension. It can be described with words, like infinity can be, but not rationally fully grasped.
When one considers that fatty acids comprise the membrane structure of all cells and their enclosed organelles, the breadth of their importance begins to emerge. Membrane fatty acids are indeed the gatekeepers of life.
The dynamic and complex: aspects of fatty acid chemistry help us to understand nutrition at a more meaningful level. Percent fat on a food label is valueless in determining the healthiness of a product. Are the fats saturated or unsaturated? If unsaturated, what are the ratios of omega 9's to 6's to 3's? Have the fats been hydrogenated? If so, what are the levels of potentially toxic trans-isomers? Are the lipids oxidized or complexed with other nutrients such as protein? Does the product contain the nutrients which were associated with the lipid in its natural context, such as antioxidants, certain vitamins, and minerals? What is the stability when subject to time, heat, light and air?
References available within book text, click the following link to view this article on wysong.net: http://www.wysong.net/articles/lipid/02_article_lipid_chapter_two_lipid_biochemistry.shtml
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The Last verse in chapter (2) of the Old Testament says:" And they were both naked, the man and his wife, and were not ashamed." The Last verse in chapter (2) of the New Testament says:" And he came and dwelt in a city called Nazareth: that it might be fulfilled which was spoken by the prophets, He shall be called a Nazarene." However, this prophecy had not been said by the prophets! The Last verse in chapter (2) of the Noble Quran says:" Allah charges no soul except to its capacity. For it is what it has earned, and against it what it has gained. 'Our Lord, do not take us to account if we have forgotten, or made a mistake. Our lord, do not burden us with a load as you have burdened those before us. Our lord, do not over burden us with more than we can bear. And pardon us, and forgive us, and have mercy on us. You are our guide, so give us victory over the unbelievers." ========
Old Testament:
Chapter two in the Old Testament is Genesis (2); it is composed of 25 verses. The Last verse is that number 25 It says:
Genesis 2:31 (King James Version) 25) And they were both naked, the man and his wife, and were not ashamed. =========
New Testament
Chapter two in the New Testament is Matthew (2); it is composed of 23 verses. The Last verse is that number 23 It says:
Matthew 2:25 (King James Version)
23) And he came and dwelt in a city called Nazareth: that it might be fulfilled which was spoken by the prophets, He shall be called a Nazarene.
However, this prophecy had not been said by the prophets! This indicates the Bible is corrupted and its writers forgot to write this prophecy! ========
The Noble Quran: Chapter two in the Noble Quran is AL-BAQARA (THE COW); it is composed of 286 verses. The Last verse is that number 286 It says:
AL-BAQARA 2:286
286) Allah charges no soul except to its capacity. For it is what it has earned, and against it what it has gained. 'Our Lord, do not take us to account if we have forgotten, or made a mistake. Our lord, do not burden us with a load as you have burdened those before us. Our lord, do not over burden us with more than we can bear. And pardon us, and forgive us, and have mercy on us. You are our guide, so give us victory over the nation, the unbelievers.'
This is one of the beautiful prayers in the Quran. ========
Back to the main issue of my series of articles; this is my question to you smart readers: "Is the Quran quoted from the Bible?"
Both Dr. Randy Wysong & Dr. Ibrahim Khalil are contributors for EditorialToday. The above articles have been edited for relevancy and timeliness. All write-ups, reviews, tips and guides published by EditorialToday.com and its partners or affiliates are for informational purposes only. They should not be used for any legal or any other type of advice. We do not endorse any author, contributor, writer or article posted by our team.
Dr. Randy Wysong has sinced written about articles on various topics from Health, Bankruptcy Chapter 11 and Bankruptcy Law. Dr. Wysong: A former veterinary clinician and surgeon, college instructor in human anatomy, physiology and the origin of life, inventor of numerous medical, surgical, nutritional, athletic and fitness products and devices, research director for the presen. Dr. Randy Wysong's top article generates over 22200 views. to your Favourites.
Dr. Ibrahim Khalil has sinced written about articles on various topics from Writing, Legal Matters and Religion. Professor Dr. Ibrahim Khalil Prof. of Clinical and Chemical Pathology, Head of Clinical Microbiology and Infection Control Unit, Ain-Shams University., Egypt. And, President of The Egyptian Society of Inventors. Member of the. Dr. Ibrahim Khalil's top article generates over 368000 views. to your Favourites.