We may experience pain as a prick, tingle, sting, burn, or ache. Medical explanations put that receptors on the skin trigger a series of events, beginning with an electrical impulse that travels from the skin to the spinal cord. The spinal cord acts as a sort of relay center where the pain signal can be blocked, enhanced, or otherwise modified before it is relayed to the brain. One area of the spinal cord in particular, called the dorsal horn is important in the reception of pain signals.

The most common destination in the brain for pain signals is the thalamus and from there to the cortex, the headquarters for complex thoughts. The thalamus also serves as the brain's storage area for images of the body and plays a key role in relaying messages between the brain and various parts of the body.

Simple as it may seem, pain is actually a very complicated process which involves an intricate interplay between a number of important chemicals in the brain and spinal cord. These chemicals are generally called neurotransmitters because they transmit nerve impulses from one cell to another.

Pain has likewise been proven to cause disruptions in daily lives of people. Sometimes, it would force them to quit their jobs thus creating a domino effect, causing social problems.

With this seemingly "powerful" effect of pain , medical scientists continue to discover means to totally stop it or at least lessen its intensity. Pain killers have flooded the market.

These may either be drugs or traditional pain killers. Tramadol is among the most popular pain killer patronized by millions. Tramadol, also available online at DrugstoreTM.com, is highly recommended because of its effectiveness is stopping pain fast. Unlike other pain relievers, Tramadol extended-release is used to treat moderate to severe chronic pain when treatment is needed around the clock.

Despite the array of commercial pain killers, medical experts believe the body's natural painkillers may yet prove to be the most promising pain relievers.
The brain, they explained, may signal the release of painkillers found in the spinal cord, including serotonin, norepinephrine, and opioid-like chemicals.

With the discovery of these natural pain killers, many pharmaceutical companies have embarked on further studies to synthesize these substances in laboratories as future medications.