Hallucinations are a positive symptom, in most cases the hallucinations suffered by schizophrenics are not the usual visual hallucinations I would imagine most people experience when ill with a temperature. The most common hallucinations in schizophrenics are auditory hallucinations, usually consisting of one or more voices, which may speak to them directly, but quite often the voices are not directed to them, but do concern them, usually in a derogatory way, making suggestions to harm themselves or others, criticizing, or giving a running commentary on their own thoughts and actions. Hallucinations can involve any of the senses, such as visual, olfactory and tactile hallucinations, but auditory are the most common in schizophrenics .
Delusions, which are false irrational beliefs, not based on reality, can take many forms, the schizophrenic may be deluded that they are more powerful or important than any other human, that they have god like powers or knowledge, they may believe they are a person from history; these delusions are referred to as delusions of grandeur They may experience paranoid delusions, that they are being persecuted and that someone or something is conspiring against them, or trying to harm them.
Negative symptoms include flattened emotional response, where almost no stimuli will provoke an emotional response; they will continue to speak in a flat toneless voice, this affect appears to only affect a schizophrenic's external emotional appearance and not their internal emotions and feelings. schizophrenics may suffer with poverty of speech and be restricted in the spontaneity and information in their speech Schizophrenics may suffer with anhedonia, an inability to experience any pleasure from activities that may have previously been pleasurable, leading to a lack of interest in recreational activities. They fail to develop close relationships and become socially withdrawn; they lack social skills and lack an interest in being with people. The schizophrenic may find that they lack energy and motivation and have no interest in the way they look and their personal hygiene.
Disorganised symptoms include bizarre behaviour, thought disorders and disorganised speech. Irrational and disorganised thoughts are probably the most important symptoms of schizophrenia, they will have difficulty in organizing their thoughts, and find it difficult to sort out from logical thoughts and non logical thoughts that any non schizophrenic would know where unreal and ridiculous
Thought possession or insertion, the schizophrenic patient believes that thoughts are not his own and are being placed in his mind by someone or something else such as aliens or god. Thought withdrawal, Schizophrenic patients may also believe that their thoughts are being removed by some kind of phonological machinery, aliens or God and that these thoughts may be broadcast or read by others. The schizophrenic patient may also suffer with thought blocking, where they may have a thought, and be talking about it, and then suddenly stop and not remember what they were saying or thinking. They may have problems with learning and will find it harder to concentrate whilst reading or watching television.
A schizophrenic whilst in conversation will change from one subject to another, Words may take on special meanings to them, either because they trigger private associations or because they pay particular attention to individual sounds rather than whole words for example 'Psychiatry' Might be heard as 'sigh kaya tree' so the schizophrenic will change the subject from psychiatry to mystical trees also they may avoid some words because they sound abusive or evil. A Schizophrenics speech may seem incomprehensible to a non schizophrenic; they will make up meaningless words, or use words which rhyme rather than making any sense .
Schizophrenics seem to lack the ability to behave in a socially acceptable way, they may collect and hoard items, sometimes even rubbish, some dress in a strange way and some are known to behave in a childlike manner or even behave in a sexually inappropriate way.
Symptoms that don't seem to belong to the three categories such as catatonia, which is a motor symptom, such as positioning themselves into a strange bodily position and remaining motionless and waxy flexibility, where their limbs can be molded into position like a statue and remain motionless for a long period of time. Negativism, which is resisting attempts and suggestions, for no apparent reason, to move or be moved or doing the exact opposite to what is requested. A patient with ambitendence will begin a movement such as going to shake a persons hand and then appear to change their mind and take the hand back Echopraxia, constant mimicking of a person when requested not to. Stereotypies, regular repetitive movements for no apparent reason 'e.g. moving the arm backwards and outwards repeatedly while saying 'but not for me'.
Abnormalities found in the brains of schizophrenics may be due to genetic factors or due to the effects from environmental factors, studies have found that the lateral ventricular in a schizophrenic patient is around 25% larger than normal, although their actual brain is fractionally smaller and has a reduced cortical volume mostly in the temporal lobes, basal ganglia and limbic structures and also sulcal widening. It has been found that schizophrenic patients have structural faults in the temporal cortex, hippocampus, basal ganglia and the prefrontal cortex which also has a reduction in grey matter and a slow metabolic rate. It has been suggested that during the second trimester of the foetal development that there is some failure in neuronal migration.
The largest risk factor for developing schizophrenia is genetic. The main studies on twins by Gottesman show that monozygotic twins have a greater risk at 48% of both developing schizophrenia compared to dizygotic twins which have 17% chance of developing schizophrenia, although this can not be proved without doubt because monozygotic twins would be treated similarly by parents and would share the same environmental influences Adoption studies backup the theory Tienari studied 155 adopted children whose natural mothers were schizophrenic. When followed up years later he found that 10.3% had developed schizophrenia, compared with only 1.1% of those without schizophrenic mothers. Parnaset backs up this theory; he studied 207 children with schizophrenic mothers and followed them up nearly 30 years later 16% developed schizophrenia compared to a low risk group which only 2% developed schizophrenia . Evidence has been found by Sherrington et al of a group of genes on chromosome 5 that might be the reason for a person being susceptible to developing schizophrenia, but it has yet to be confirmed .
The symptoms of schizophrenia are so varied from self neglect and social withdrawal, to delusions and hallucinations, and not all being present in every case. The wide range of abnormalities in the brain could possibly explain why there is such a wide range of symptoms. Considering all of the genetic and environmental factors that play a role in its occurrence research seems to point towards genetics being the main factor and environmental factors playing a part in triggering the onset of schizophrenia.
As any other medical problem, hypothyroidism develops some symptoms. Hypothyroidism or underactive thyroid consists of the following symptoms: exceeded weight gain and a round and puffy face, loss of the eyebrows, abnormal reactions to cold, low sex drive. These general symptoms might come along with other specific symptoms such as abdominal bloating, cold hands and feet, dry and thin hair, muscle or even joint pain, a thicken skin or thin, brittle fingernails.
These specific hypothyroidism symptoms can be divided into two groups depending on the stage of the disease.
The early symptoms are generally attributed to stress or aging. These early hypothyroidism symptoms generally consist of a permanent tiredness and oversensitivity to cold. Among the general symptoms mentioned earlier we have to remember that cold intolerance, exceeded tiredness, muscle or joint aches and weight gain can be considered early symptoms of hypothyroidism. Beside these mentioned problems constipation may also cause discomfort during this disease. For premenopausal women hypothyroidism is equivalent with heavy periods experiences.
During the early stages, while experiencing the symptoms mentioned earlier, the patients’ skin becomes rough and dry, hair coarsens and mental problems may occur. All these problems and side effects are caused by the fall of the thyroid hormone levels.
Some specialists say that depressions may occur even in the early stages and believe that a mild thyroid failure may lead to major depressions.
These are the early symptoms. For persons that leave hypothyroidism untreated the later symptoms may occur. In most of the cases the later symptoms include the physical changes. These changes refer to a round and puffy face, with a sleepy appearance, to a dry and rough skin and to hair loss. The later symptoms also include a husky voice and numbness of the arms and legs. Just as in the early stage, symptoms such as muscle pain and weakness may occur but at different intensities. In some people, symptoms like hair loss or even mental confusion may be observed. Hypothyroidism may also lead to memory problems or daytime sleepiness. The most risky condition that may develop from hypothyroidism is myxedema coma. This condition is a life threatening one.
It is also good to know that secondary hypothyroidism is not common because it is caused by an abnormality of the pituitary gland and deficient TRH secretion.
For children and infants the symptoms of hypothyroidism are different. For them it is necessary a fast treatment prescription because this condition might lead to retardation. The common symptoms for the younger ones are feeding problems, constipation, hoarseness and sleepiness. In later stages, babies might develop rough and dry skin, protruding abdomen and delayed teething.
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