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Your Online Guide » Guide to Women » Breast Cancer

[S444]Side Effects Of Radiotherapy
by Bello Kamorudeen, Bel

Side effects of chest radiotherapy

Radiation treatment to the chest in the treatment of pleural mesothelioma may cause swallowing problems, cough, or shortness of breath. You should inform your doctor if you notice any of these side effects.

Other side effects may include breast soreness and swelling from fluid build-up in the treated area. These side effects most likely will go away a month or 2 after you finish radiation therapy. If fluid build-up continues to be a problem (a condition called lymphedema), ask your doctor what steps you can take.

Skin in the treated area may turn red or get darker. This will most likely fade 1 or 2 months after you finish the radiotherapy treatment.
When radiation treatments include the chest area, the lungs can be affected. One early change is a decrease in the levels of surfactant, the substance that helps keep the air passages open. This keeps the lungs from fully expanding, and may cause shortness of breath or cough. These symptoms are sometimes treated with steroids.

A possible late effect of radiation to the lungs is fibrosis (stiffening or scarring). When this happens, the lungs can no longer fully inflate and take in air. If a large area of the lungs is treated with radiation, these changes can cause shortness of breath and less tolerance for physical activity.

Side effects of abdominal radiotherapy.

If you are having radiation treatment to the stomach or some part of the abdomen (belly) for the treatment of abdominal mesothelioma, you may experience symptoms of vomiting, nausea, or diarrhea. Your doctor can give you medicines to help relieve these symptoms. You might also consider the use of home remedies, but make sure you discuss with your health team about these home remedies before taking them.

Managing nausea

You could feel nauseated a few hours right after completion of radiation therapy. If you are experiencing this symptom it is better that you do not take any meal several hours before you commence treatment. You may be able to handle the treatment better on an empty stomach. After treatment, you may want to wait 1 to 2 hours before eating. If the problem persists, ask your doctor about medicines to prevent and treat nausea. Be sure to take the medicine as prescribed.

If you notice nausea before your treatment, eat a bland snack, such as toast or crackers, and try to relax as much as possible. Here are some tips to help an upset stomach:

•Stick to any special diet your doctor or dietitian gives you.

•Eat small meals.

•Eat often and try to eat and drink slowly.

•Avoid fatty and fried foods.

•Drink cool liquids between meals.

•Avoid meals that have a strong aroma, and eat meals that are served cool or at room temperature.

•For a severe upset stomach, try a clear liquid diet (broth and juices) or bland foods that are easy to digest, such as dry toast and gelatin.

•Learn deep breathing and relaxation techniques, and try them when you feel nauseated.

How to manage diarrhea

Diarrhea usually starts a few weeks after starting radiation therapy. Your doctor may prescribe medicine or give you special instructions to help with the problem. Your doctor may also recommend that you modify your diet in the following ways:

•Try a clear liquid diet (water, weak tea, apple juice, peach nectar, clear broth, popsicles, and plain gelatin) as soon as diarrhea starts or when you feel it is going to start.

•Avoid foods that are high in fiber or can cause gas or cramps, such as raw fruits and vegetables, coffee, beans, cabbage, whole grain breads and cereals, sweets, and spicy foods.

•Avoid taking large meals, it is better you take light frequent meals instead.

•If taking of milk and milk products irritate your bowels, the avoid taking them.

•Once the diarrhea starts resolving, eat small amounts of low-fiber foods such as rice, bananas, applesauce, yogurt, mashed potatoes, low-fat cottage cheese, and dry toast.

•Take food that are rich in potassium (bananas, potatoes, apricots, peaches), this mineral is lost from the body through diarrhea.

Diet planning is an important part of radiation treatment of the stomach and abdomen. Most of these symptoms will abate once treatment is over. In the meantime, try to pack the highest possible food value into even small meals so you get enough calories, vitamins, and minerals.


How to Take Allopurinol

Take Allopurinol exactly as prescribed by health care provider. Allopurinol is generally available in market in the form of Powder for injection, lyophilized 500 mg, Tablets 100 mg, Tablets 300 mg. Administer immediately after meals. For patients who have difficulty swallowing, crush tablets and mix with food. Reduced dose is given in patients with this condition. Drug may exacerbate renal failure in certain patients.

Indications for Allopurinol Drug

*Tablets: Treatment of primary or secondary gout, hyperuricemia resulting from chemotherapy for malignancies, recurrent calcium oxalate renal calculi.
*Tablets and injections: Management of patients with leukemia, lymphoma, and solid tumor malignancies when concurrently receiving cancer therapy that causes elevations of serum and urinary uric acid levels. Use injection in patients who cannot tolerate oral therapy.

Interactions for Allopurinol Drug

*Aluminum salts, uricosuric agents: May lessen effectiveness of allopurinol.
*Ampicillin: May increase incidence of ampicillin-induced skin rash.
*Cyclophosphamide: May enhance bone marrow suppression.
*Theophyllines: Theophylline clearance may be decreased, leading to toxicity.
*Thiopurines (eg, azathioprine, mercaptopurine): Toxicity of these drugs may be increased.

Drugs that are physically incompatible in solution with allopurinol sodium for injection are the following: amikacin; amphotericin B; carmustine; cefotaxime; chlorpromazine; cimetidine; clindamycin; cytarabine; dacarbazine; daunorubicin; diphenhydramine; doxorubicin; doxycycline; droperidol; floxuridine; gentamicin; haloperidol; hydroxyzine; idarubicin; imipenem plus cilastatin; mechlorethamine; meperidine; metoclopramide; methylprednisolone sodium succinate; minocycline; nalbuphine; netilmicin; ondansetron; prochlorperazine edisylate; promethazine; sodium bicarbonate; streptozocin; tobramycin; vinorelbine tartrate.

What are the Side Effects of Allopurinol -

Like other medicines, Allopurinol can cause side effects. Some of the more common side effects of Allopurinol include

* Drowsiness; generalized seizure (injectable); headache; neuritis; paresthesias; peripheral neuropathy.
* Allergic vasculitis; alopecia; ecchymosis; skin rash. Allergic reactions may be severe and sometimes fatal.
* Abdominal pain; diarrhea; dyspepsia; gastritis; granulomatous changes; nausea; vomiting.
* Epistaxis; myopathy; taste disturbance.
* Renal failure; uremia.
* Bone marrow depression; eosinophilia; leukocytosis; leukopenia; thrombocytopenia.
* Cholestatic jaundice; elevated liver enzymes; hepatic necrosis; hepatitis; reversible hepatomegaly.
* Acute gouty attacks; arthralgia; fever; myopathy; necrotizing angiitis.

Warnings and precautions before taking Allopurinol :

* Advise patient before using Allopurinol that drug may cause drowsiness, and to use caution while driving or performing other tasks requiring mental alertness.
* Instruct patient before using Allopurinol to stop taking medication and notify health care provider if rash or flu-like symptoms develop.
* If urine output is decreased, dosage may need to be decreased. Consult health care provider before using Allopurinol.
* Advise women before using Allopurinol to inform health care provider if pregnant, planning to become pregnant, or breastfeeding while taking Allopurinol. Insulin is recommended to maintain blood glucose levels during pregnancy. Prolonged severe neonatal hypoglycemia can occur if sulfonylureas are administered at time of delivery.
* For treatment of gout, obtain baseline uric acid level. Monitor q 1 to 2 wk for dosage adjustment, then monitor every few months.

What if Overdose of Allopurinol ?

If you think you or anyone else taken overdose of Allopurinol , immediately telephone your doctor or contact your local or regional Poisons Information Centre Seek medical attention immediately. You may need urgent medical attention. Chills, headache, arthralgia, sinusitis are may be the overdose symptoms of Allopurinol.

What if Missed Dose of Allopurinol ?

If you miss a dose of Allopurinol medicine and you remember within an hour or so, take the dose immediately. If you do not remember until later, skip the dose you missed and go back to your regular schedule. Do not double doses.

Storage Conditions for Allopurinol :

Store Allopurinol reconstituted solution at 20° to 25°C; do not refrigerate or dilute product. Store Allopurinol unreconstituted powder at room temperature. Store Allopurinol tablets in tightly closed container in cool location.

By: ashu

Article Source : Breast Cancer

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Both Bello Kamorudeen & Alison White are contributors for EditorialToday. The above articles have been edited for relevancy and timeliness. All write-ups, reviews, tips and guides published by EditorialToday.com and its partners or affiliates are for informational purposes only. They should not be used for any legal or any other type of advice. We do not endorse any author, contributor, writer or article posted by our team.

Bello Kamorudeen has sinced written about articles on various topics from SEO linking, Breast Cancer and Medical Related. . Bello Kamorudeen's top article generates over 27100 views. to your Favourites.

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