A new study released Tuesday, three new drugs; rituximab, abatacept and tocilizumab are on the cutting edge of science. Rheumatoid arthritis is a chronic inflammatory joint disease that attacks the joints, producing harsh pain, stiffness and swelling. Rituximab and abatacept have already received approval to treat of patients who suffer from this painful illness. Tocilizumab is still in phase III clinical trials testing.
According to HealthDay, Traditional treatments for rheumatoid arthritis include nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, and disease-modifying anti-rheumatic drugs (DMARDs), which include the widely used Methotrexate. But only DMARDs, and to a certain extent glucocorticoids, can slow or halt rheumatoid arthritis' inflammatory and destructive disease processes, according to background information in the study. Rituxamab targets the CD20 antigen in certain cells, leading to a reduction in the CD20 cell count. Abatacept interferes with T-cell activation response, believed to play an important role in rheumatoid arthritis. Tocilizumab targets interleukin-6, which activates many cell populations.
All three forms of treatment have been found to improve signs of arthritis and symptoms, improve patients' physical function and health status, and delay progression of joint damage. All have all been found affective as both stand alone treatments and when used in conjunction with alternate remedies. Although still unapproved, intitial trials of rituximad found that the drug reduced arthritis symptoms by 50 percent for 1/3 of its test group.
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Rheumatoid Arthritis is a disease whose symptoms include chronic inflammation or swelling of the joints. In the long term, it can lead to joint damage, pain, stiffness and problems with mobility. Rheumatoid Arthritis is a chronic disease. That means that it may never go away. According to the Arthritis Foundation, it is also a systemic disease which means that Rheumatoid Arthritis can affect other systems or organs in your body. It is a very serious disease which needs early diagnosis and treatment in order to help you continue living as normally as possible. The cause of Rheumatoid Arthritis is still unknown. What is known is that people with this disease have an abnormal immune system. People with Rheumatoid Arthritis have immune systems that think that healthy joint tissue is a foreign body and the person's own immune system attacks the joint. It is still a disease that has no cure. Rheumatoid Arthritis is treated in ways designed to preserve mobility and reduce pain and inflammation. Most sufferers will first notice rheumatoid arthritis in the smaller joints of their hands and wrists, beginning with warmness around the joints or stiffness and inflammation. Rheumatoid arthritis affects both sides of the body equally, so if your right hand is affect then your left will be as well. Oftentimes after it begins to affect the smaller joints of the body it will then progress to the larger joints of the hips and knees. A small percentage of the population is affected by this disease. According to the Arthritis Foundation, about 70% of the victims of the disease are women who first experience symptoms between the ages of 30 to 50 years. Although not common, this disease can also occur in children affecting girls more often than boys. Each case of rheumatoid arthritis is managed in its own way, since the disease can present itself so differently in each person. Depending on the progression of the disease, the amount of inflammation and pain, different drugs are prescribed. Anti-inflammatory drugs, pain killers, anti-rheumatic and immune system drugs are a part of a normal drug cocktail for a person with rheumatoid arthritis. Your doctor may also recommend some other types of therapy to help with your arthritis, such as physiotherapy or acupuncture, which can help naturally relieve symptoms as well as keep your joints more limber and pain free. No matter who you are, if you feel the symptoms of rheumatoid arthritis such as warmth and inflammation in the joints in the hands, you should see your doctor immediately. Diagnosing and treating rheumatoid arthritis early will increase your chances of slowing down the disease and leading a normal, healthy life.
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