Erythema dyschromicum perstans (EDP) is a rare disorder of pigmentation that is most common in Hispanic patients. The condition occurs worldwide. It is usually develops before 40 years of age. Although there is predilection for the trunk, the lesions may be widespread and are symmetric throughout the body. Nails and mucosa are not affected. The active lesions of LP gradually evolved into typical ashy-gray macules of EDP. Erythema dyschromicum perstans is considered a variant of lichen planus. Since both lesions have occurred simultaneously in the same patient with similar immunopathologic findings, some believe lichen planus pigmentosus to be the same condition.

A palpable erythematous ridge characterizes the lesions' periphery. High-potency topical corticosteroids may produce a response. There is also evidence of anti-inflammatory and immunomodulatory effects on this condition. Treatment with oral dapsone or clofazimine for several months has been helpful. More than 50% of clofazimine-treated patients report complete resolution. Use of sunless tanning products may be of cosmetic value. Direct immunofluorescence findings of cytoid bodies provide further support for this hypothesis. Clofazamine given over several months appears to have benefit in a majority of patients. There is also evidence of anti-inflammatory and immunomodulatory effects on this condition.

Erythema Dyschromicum - Prevention and Treatment Tips

1. Oral dapsone or clofazimine is helpful for treat erythema dyschromicum.

2. Use of sunless tanning products may be of cosmetic value.

3. Clofazamine given over several months appears to have benefit in a majority of patients.

4. Electron microscopy shows apoptosis and residual filamentous bodies.