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Causes Of Pulmonary Hypertension

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Primary Pulmonary Hypertension, commonly referred to as PPH, is caused by an increased pressure within the pulmonary arteries which carry blood from your heart to your lungs. This eventually leads to the thickening of the arteries and narrowing of the arterial passageways, which further obstruct the flow of blood.



In an effort to compensate for poor circulation, the right side of your heart becomes enlarged, and the extra work the heart must do can eventually cause right-sided heart failure. Primary Pulmonary Hypertension complications can occur in the form of liver failure, kidney failure, or heart failure.

While the specific cause of Primary Pulmonary Hypertension is not known, there are a variety of causes which have been found to contribute to Primary Pulmonary Hypertension. One of these is the appetite suppressant known as Fen-Phen, which has been shown to constrict or narrow the pulmonary artery.

Fen-Phen was prescribed as a weight loss drug in the 1960s, and it is estimated that over 20 million people were found to use Fen-Phen in their weight loss treatment. However, due to an overwhelming occurrence of abnormal echocardiograms, the FDA was forced to take the drug Fen-Phen off the market in 1997.

Studies commenced regarding the use of Fen-Phen as it related to Primary Pulmonary Hypertension, and it was found that there was a direct relationship between this drug and vascular heart disease and Primary Pulmonary Hypertension. Unfortunately, even though patients stopped taking the diet drug Fen-Phen, they were already marked for developing this disease.

Medical experts have noted that there was a potential latency of ten or more years between the last date on which the patient was exposed to the drug Fen-Phen and the time at which the patient developed the first symptoms of Primary Pulmonary Hypertension. Thus, cases of PPH continue to occur today in those people who had taken Fen-Phen alone or in combination with other weight loss drugs.

Moreover, there have been a myriad of lawsuits against the drug company, and many patients have sought a Primary Pulmonary Hypertension lawyer who specializes in this specific area to seek compensation for, and as a result of, PPH complications which occurred.

It is revealed that women are five times more likely than men to develop PPH. While there are often no symptoms of this disease until the condition is advanced, the main symptom is swollen ankles. In addition, your skin may have a bluish tinge because the blood contains less oxygen that it should.

The low oxygen content of the blood stimulates the production of more red blood cells. When the red cell count becomes too great, the blood becomes thicker and harder to push through the small vessels of the lung, further increasing the pulmonary artery blood pressure and decreasing the cardiac output.

Primary Pulmonary Hypertension complications can cause right-sided heart failure. If you have been experiencing breathlessness because of underlying lung disease, PPH is likely to make you even more breathless, and you may also experience other symptoms associated with right-sided heart failure.

One of the symptoms of right-sided heart failure is fatigue and swelling of the lowest part of your body from accumulation of fluid. Some of the signs you should look for is if you are up and about, your ankles may swell. If you are bedridden, the swelling will be most noticeable in the lower part of your back.

Internal organs such as the liver can also become swollen, and this can result in abdominal pain. Additional Primary Pulmonary Hypertension complications can occur in the form of congestive heart failure, which is when both the right and left side of the heart fail.

If you were prescribed Fen-Phen for weight loss, and are now exhibiting symptoms of Primary Pulmonary Hypertension, you should contact a PPH lawyer. You are entitled to seek damages by utilizing the services of a PPH lawyer. If either you or someone you know has suffered damages related to the use of Fen-Phen, including Primary Pulmonary Hypertension, it is important to proceed with claims to recover damages with the assistance of a PPH lawyer. You can receive compensation for pain and suffering, lost earnings, medical expenses, and punitive damages.

Unfortunately, since Fen-Phen was taken off the market, there are millions of people who have reported symptoms associated with Primary Pulmonary Hypertension. Make no mistake; this condition can be deadly as it affects the primary heart muscles which can lead to heart failure.

If you are suffering ill effects of the drug Fen-Phen, it is incumbent upon you to seek a pulmonary specialist who can diagnose your condition and determine the extent of PPH. It is further advised that you contact a PPH lawyer immediately.
Causes Of Pulmonary Hypertension
These studies have raised an alarming dialogue among PPH specialists and other experts in which anti-depressants used by pregnant women can increase the chances of their babies being born with lung problems, specifically Primary Pulmonary Hypertension.

The drugs in question are well known. They include: Celexa, Prozac, Paxil, and Zoloft.

Consequently, babies born with Primary Pulmonary Hypertension require immediate assistance in order to breathe. Unfortunately, it is estimated that 10 to 20 percent of these babies will die soon after birth.

Moreover, those born with Primary Pulmonary Hypertension will undoubtedly develop hearing loss, brain abnormalities, and dysfunction in development and seek assistance from a PPH specialist.

Although experts claim the risk of having a child born with Primary Pulmonary Hypertension is very low, women who do take any of these anti-depressants are taking a chance with their unborn. It was also found that women who are still viable to have children, but have depression issues, are more likely to take anti-depressants.

In response to these underlying facts, the FDA concluded that more safety studies were needed, but at the same time, women who do take anti-depressants should not stop due to this report.

But the fact remains that newborns do develop symptoms such as poor eating, seizures, and anxiety. Therefore, one must seek the guidance and assistance of a PPH specialist. One such study reported that 30 per cent of infants exposed to anti-depressants in the womb developed a sugar imbalance, sleep disturbances, and symptoms akin to drug withdrawal.

Consequently, the FDA warned that the use of Paxil during the first trimester is associated with increased risk of birth abnormalities such as cardiac defects. However, it did not end there. According to the Johnson Law Group who practices pharmaceutical litigation in general, and cases relating to Paxil in particular, they discuss the problems of Paxil as a prescribed drug in this way: More than 20 million Americans take antidepressants.

Last year doctors dispensed 150 million prescriptions in the United States, according to IMS Health, a Connecticut-based health care information company. As much as 70 percent of the drugs are prescribed not by psychiatrists but by general practitioners with no special training in complex mental disorders. The overall market for antidepressants in the United States is more than $12.5 billion annually.

Moreover, they proclaim that the FDA alerted health care professionasl and patients about new studies suggesting that Paxil increased the risk of birth defects, particularly heart defects, when women took the drug during the first three months of pregnancy. Early results of two studies showed that women who took Paxil during the first three months of pregnancy were about two times more likely to have a baby with a heart defect than women who received other antidepressants or women in the general population.

Most of the heart defects reported in these studies were atrial and ventricular septal defects (holes in the walls of the chambers of the heart). In general, the FDA said, these defects range in severity from those that are minor and may resolve without treatment to those that cause serious problems and may need to be repaired surgically.

That warning was followed with another alert from the FDA in July 2006 that reported that the use of antidepressants by pregnant mothers resulted in babies born with a serious condition called persistent pulmonary hypertension (PPHN). Babies born with PPHN have abnormal blood flow through the heart and lungs and do not get enough oxygen to their bodies. Babies with PPHN can become very sick and possibly even die.

The results of this study, reported by The New England Journal of Medicine, showed that babies born to mothers who took SSRIs, the family of drugs that Paxil belongs to, were six times more likely to have PPHN than babies born to mothers who did not take antidepressants during pregnancy.

In another study, the higher incidence of Primary Pulmonary Hypertension did not occur in women who took non-SSRI antidepressants. These include tricyclics such as Elavil, Wellbutrin, Effexor, and Desyrel. The bottom line is that there is a need for more information about the safety and uses of drugs during pregnancy. Seeking advice from a PPH specialist in consultation with a pediatric doctor may be recommended.

If you have been taking Paxil during pregnancy, and your newborn showed signs of either Primary Pulmonary Hypertension, birth defects or serious illness, it is incumbent upon you to contact a PPH attorney to commence litigation on your behalf. While the loss of a child can never be fully measured in monetary value, you may need to seek compensation for additional medical treatment as a result of this devastating loss.
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