is a disease created by a buildup of uric acid. In this condition, crystals of monosodium urate or are collected on the articular cartilage of joints, tendons and surrounding tissues. These crystals cause inflammation and ache, both intense. If no treated, the crystals form tophi, which might cause obvious tissue damage. Gout results from a combination of increased saturations of uric acid and general acidity in the bloodstream.Gout is characterized by excruciating, sudden, unexpected, burning pain, as well as swelling, redness, warmth, and stiffness in the affected joint. This occurs commonly in men in their toes but can occur in other parts of the body and affects ladies as well. Slight fever may also be present. The patient mainly suffers from two sources of pain. The crystals within the joint cause intense ache everytime the affected area is moved. The inflammation of the tissues [surrounding the joint also causes the skin to be swollen, soft and sore if it is even slightly touched. Gout usually affects the big toe (approximately 75 percent of first attacks); however, it also can affect other joints such as the ankle, heel, instep, knee, wrist, elbow, fingers, and spine. Rarely, the condition may appear in the joints of small toes that have become motionlessstaticdue to impact injury earlier in life, resulting in poor blood circulation that leads to gout.A category of people have mutations in the proteins responsible for the excretion of uric acid by the kidneys.The high levels of uric acid in the blood are caused by protein rich foods. Alcohol intake often causes severe attacks of gout and hereditary factors can contribute to the elevation of uric acid. Typically, persons with gout are fat, predisposed to diabetes and hypertension, and at higher risk of heart disease. Gout is more prevalent in prosperous societies due to a diet rich in proteins, fat, and alcohol. If it is a result of other health problems such as renal failure, it is often regardless of the person's lifestyle.A definitive diagnosis of gout is from light microscopy of liquid aspirated from the affected joint or other locus to demonstrate intracellular monosodium urate crystals in synovial fluid polymorphonuclear leukocytes.The urate crystal is identified by strong negative birefringence under polarised microscopy and its needle-like morphology. A trained observer does better in distinguishing them from other crystals. Many physicians do not prescribe this test, relying otherwise on a variety of less specific clinical signs and laboratory tests.Hyperuricemia is a universal feature of gout, so its presence supports a diagnosis of gout. However, gout can occur without hyperuricemia.Hyperuricemia is when uric acid level is high , but that does not evidently point out a person will develop gout. Prevention of chronic gout has a different objectives than tackling severe episodes (flareups). In an severe attack the objective is to reduce pain and inflammation. The objective of prevention is to stop any future attacks and associated cumulative tissue damage. Prevention strategies include reducing the supply of purine, dissolving crystals of uric acid so the uric acid can return to the blood, and increasing the excretion of uric acid from the blood into the urine. Prevention tactics involve careful diagnosis of the reasons contributing to the gout, followed by correct use of medication, diet, and over the counter remedies.