A number of benign and malignant tumours occur in the lungs but the primary lung cancer, commonly termed bronchogenic carcinoma, is the most common. The lung is also the commonest site for metastasis from carcinomas and sarcomas. A histologic classification of various benign and malignant tumours of lungs as recommended by the World Health Organisation
It is the most common primary malignant tumour in men inindustrialised nations and accounts for nearly one-third of all cancer deaths in both sexes. Currently, the incidence in females in the United States has already exceeded breast cancer as a cause of death in women. Cancer of the lung is a disease of middle and late life with peak incidence in 5th to 7th decades, after which there is gradual fall in its incidence.
ETIOPATHOGENESIS
1. Smoking :
2. Atmospheric pollution
3. Occupational causes
4. Dietary factors
5. Genetic factors
6. Chronic Scarring
TUBERCULOSIS
Tuberculosis (commonly shortened to TB) is an infection caused by the bacterium Mycobacterium tuberculosis. TB most commonly affects the lungs (pulmonary TB) but can also affect the central nervous system (CNS)(meningitis), lymphatic system, circulatory system (Miliary tuberculosis), genitourinary system, bones and joints.
Tuberculosis is one of the most deadly and common major infectious diseases today, infecting more than two billion people, or approximately one-third of the world's population. Nine million new cases of disease, resulting in two million deaths, occur annually, mostly in developing countries. However, developed countries are not spared the burden of tuberculosis.
Tissue response in tuberculosis represents classical example of chronic granulomatous inflammation in humans.the causative agent is tubercle bacillus or Koch bacillus called Mycobacterium tuberculousis causes tuberculosis in the lung and other tissues of the human body. The organism is a strict aerobe and thrives best in tissues with oxygen tension like in the apex of the lung.
Mode Of Transmission
1. Inhalation of organisms present in fresh cough droplets or in dried sputum form an open case of pulmonary tuberculosis.
2. Ingestion of the organisms leads to development of tonsillar or intestinal tuberculosis. This mode of infection of human tubercle bacilli is from self-swallowing of infected sputum of an open case of pulmonary tuberculosis, or ingestion of bovine tubercle bacilli from milk of diseased cows.
3. Inoculation of the organisms into the skin may rarely occur from infected postmorten tissue.
TB is spread by aerosol droplets expelled by people with active TB disease of the lungs when they cough, sneeze, speak, or spit. Each droplet is 5 ?m in diameter and contains 1 to 3 bacilli. Close contacts (people with prolonged, frequent, or intense contact) are at highest risk of becoming infected (typically a 22% infection rate). A person with untreated, active tuberculosis can infect an estimated 20 other people per year.
Lung Cancer In Smokers
Lung cancer is an ailment of unrestrained cell development in the lung tissues. This growth may lead to metastasis, spreading to the adjoining tissues and penetrating prematurely the lungs.
Lung cancer is the most popular cancer cause of death in men, and the second most common in women.
Frequent symptoms of lung cancer:
1. Continuous chest throbbing
2. Persistent coughs that become severe
3. Shortness of breath, puffing, or huskiness
4. Constant troubles with pneumonia or bronchitis
5. Coughing up blood
6. Inflammation of the neck and face
7. Loss of appetite or significant weight loss
8. Exhaustion
Types of Lung Cancers:
A. Small-cell lung cancer occurs when malignant cells form in the lung tissues.
Small lung cancer has three different types, classified according to the forms of cells developing as cancer. These are:
1. Small cell carcinoma
2. Union of small cell and large cell carcinoma.
3. Joint small cell carcinoma.
These three kinds may contain many different types of cells. The cancer cells of all types may grow and multiply in different ways.
Stages of Small Cell Lung Cancer
Limited stage - cancer starts in the lung tissues, and in the adjacent lymph nodes. Lymph nodes are tiny, bean-shaped structures near the lungs.
Extensive Stage – cancer has propagated beyond the lungs to other parts of the body.
B. Large-cell lung cancer is a disease in which malignant cells form in the tissues of the lungs.
Five types of large-cell lung cancer
The five types of large-cell lung cancer have differing varieties of cancer cells. The cancer cells of each category produce and multiply in unusual effects:
1. Squamous cell carcinoma – Cancer starts in the squamous cells, thin flat cells that appear like fish scales. It's called epidermoid carcinoma.
2. Large cell carcinoma – Cancer in which the cells are big and seem to be irregular when examined under a microscope.
3. Adenosquamous carcinoma – Cancer that begins in cells. Cancer cells appear to be firm when inspected under a microscope.
4. Adenocarcinoma – Cancer that begins in groups in glandular assets.
5. Undifferentiated carcinoma – Cancer cells that do not seem to be normal. They spread fast.
Treatment:
1. Surgery - Surgery is the ideal medication for lung cancer. The body is normally opened up for the lungs to be treated directly.
2. Radiation is a common treatment for lung cancer. Radiation therapy utilizes high-energy rays to destroy cancer cells. It distresses cells only in the treated area.
a. External radiation is the most common radiation treatment for people with lung cancer. Radiation comes from a huge apparatus outside your body. Mainly people go to the hospital or clinic for treatment. Treatments are typically 5 days a week for more than a few weeks.
b. Internal radiation is rare. Radiation is released from a seed, wire, or another device, to the body.
Treatment of Large-Cell Lung Cancer:
• Chemotherapy – This is cancer treatment making use of drugs to prevent the increase of cancer cells. Drugs are either taken by mouth or injected in the veins and muscles to destroy cancer cells. These drugs go into the bloodstream to treat cancer cells in the body. When chemotherapy is placed straight in the spinal column, an organ, or a body cavity like the abdomen, these drugs generally distress cancer cells in those parts.
• Laser therapy – Laser is used to destroy cancer cells.
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