For a period of time in recent history, antibiotics were heralded as being the most effective possible treatment for infectious diseases. Most of those illnesses were caused by bacterial agents, so the use of medications that killed off harmful bacteria was a sensible, practical solution. However, there is no clear indication that anyone within the medical or scientific communities saw the rapid evolution of antibiotic resistance coming. Even if someone did, history certainly doesn't reflect it all that well. Regardless of the slip-up of the past, it is now understood that the typical antibiotic has a limited lifespan now, being rendered nearly useless as soon as the bacterial agent they target has developed resistance to their effects. This was the case with tuberculosis, which was once thought to have been wiped out in the developed world, and is the case with many other bacterial infections.
The problem of dealing with antibiotic resistance is a complex one. Some bacterial agents have developed their resistance only to certain agents ? though those agents are the ones that are prescribed as treatment. Other microbes, on the other hand, have developed effective antibiotic resistance to all antimicrobial agents currently available on the market. This situation, some public health officials worry, is bound to cause major problems. A number of experts are pointing out the gradual increase in the number of resistant cases of tuberculosis to be an indication of the possible damage this problem can cause. With tuberculosis being resistant to all the current drugs used against it, treatment for patients with the resistant strain is becoming more and more difficult, and the disease is becoming more and more fatal.
One single illness that has antibiotic resistance does not a major public health problem make. Most authorities in the medical field would not be worried if there wasn't evidence that other bacterial infections are starting to prove as resilient as the common cold. The common cold has long been a problem for medicine, such that being able to develop a cure for it has long been considered impossible. The bacteria at the root of the cold adapts with a rapid pace, becoming resistant to the effects of medication used to treat it the year before. While hardly something that is life-threatening, there is a very strong possibility that other, more dangerous bacterial agents might emerge with the same level of adaptability. Another possible scenario involves multiple bacterial agents developing resistance and reemerging into the public arena. Their infectious nature and antibiotic resistance, plus the relative degree of congestion in the average urban area, nearly guarantees a rapid spread of infection.
If this sounds like a bad plot for a doomsday scenario in a science fiction novel, that's because said scenarios may not really be that far off the mark. Bacterial adaptation against countermeasures being used against them is at a much faster rate than how fast researchers can develop new antibiotic medication. For example, a hospital in Switzerland found that, within a period of three years, the strains of Escherichia coli that they encountered developed resistance to all five known types of antibacterial agents for it. They have also noted that this sudden increase in resistance was linked to the increased use of said antimicrobial agents, which has caused some to believe that the very success and widespread use of antibiotics is the root cause of the problem. The more bacteria are exposed to the medication, the higher the chances that a mutated strain will emerge that is resistant to the effects.
Mechanisms Of Antibiotic Resistance
This was the consensus of medical experts at the 22nd International Congress of Chemotherapy in Amsterdam. The congress brought together nearly 3,000 delegates from all over the world representing more than 60 member societies of the International Society of Chemotherapy.
During the symposium, new data were presented showing the alarming problem of antibacterial resistance in many parts of the world, owing largely to the uncontrolled and inappropriate use of antibiotics in both industrial and developing countries.
One of the speakers, Dr. Dieter Adam, professor of pediatrics at the Kinderklinik der Universitat Munchen in Munich, Germany, noted the high incidence of antibacterial resistance to two commonly prescribed antibiotics - penicillin and macrolides - in Hong Kong, France, Spain and Greece. He attributed the problem to the availability of antibiotics over the counter, wrong prescription practices, low-priced generic brands, and poor patient compliance.
Because of this, treatment of RTIs like pneumonia, tonsillitis and bronchitis has become difficult and a burden to many patients around the world. Dr. Robert Cohen, a pediatrician at the Department of Microbiology, Hospital Intercommunal de Creteil in France, added that RTIs account for more than 50 percent of consultations and more than 75 percent of antibiotic prescriptions.
In his report titled, "Infections of the airways" published in Current Opinion on Infectious Diseases. Dr. R. Wilson said new drugs are required to combat the growing menace of RTIs that affect millions of people worldwide - both young and old alike.
"Until recently, the antibiotics available for the management of RTIs were adequate and there was less of a need for new agents. However now that common pathogens are more likely to be resistant to currently prescribed antibiotics and new pathogens are being recognized, the situation has changed," Wilson said.
In America alone, RTIs are among the Top 10 causes of death in the elderly and cost the nation more than $24 billion yearly. In Switzerland, RTIs account for almost 50 percent of pediatric consultations and over 3 million working days are lost because of the disease.
In addition to the continued loss of work and school days, RTIs weaken the body's natural immune system, eventually leading to the deterioration of pulmonary function.
Another researcher, Dr. P. Bell, who said that there is a need for more judicious use of antibiotics, shares Wilson's sentiments. He said that in the United Kingdom, over 25 million antibiotic prescriptions are given yearly but many of these are unnecessary and contribute mainly to antibiotic resistance.
"After 40 years of antibiotic use, it appears that other strategies will be necessary in the present decade to eradicate RTIs," said Dr. J.M. Bernstein in Respiration.
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Harvey Ong has sinced written about articles on various topics from Acupuncture Chiropractor, Birth Control and Online Dating. Harvey Ong is currently employed as a researcher for an online media company, currently writing about pharmaceutical products and herbal remedies. He is also an amateur paleontologist and has a collection of various animal toxins, for research reasons.. Harvey Ong's top article generates over 18100 views. to your Favourites.
Janet Martin has sinced written about articles on various topics from Womens Health, Pregnancy Problems and Asthma. Janet Martin is an avid health and fitness enthusiast and published author. Many of her insightful articles can be found at the premiere online news magazine
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