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Neovascular Age Related Macular Degeneration

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Researchers have looked at the benefit of individual nutrients for fighting AMD, but only recently has anyone looked at total antioxidant status or total circulating blood levels of various antioxidants. Japanese researchers recently measured levels of various antioxidants in people that did and did not have AMD.



Only low levels of vitamin E and cryptoxanthin (an antioxidant in the carotenoid family) were found in people that had AMD. But, those people that did not have AMD had higher circulating levels of a variety of different antioxidants. They concluded that antioxidants found in the traditional Japanese diet provide protection against AMD.

Other studies have demonstrated that high concentrations of antioxidants in the bloodstream protect the health of the heart and the kidneys. They are associated with a reduced risk of various types of cancer, as well. So, for your overall health, a zeaxanthin formula that includes a variety of different antioxidants is your best choice.

Of course, a diet rich in fruits and vegetables is also wise. You can't expect to go around eating junk food all of your life, without developing some kind of chronic or life threatening disease. But, if you haven't always been perfect, there are some antioxidants that actually counteract the negative effects of a high fat junk-food diet. One of them is resveratrol.

When it comes to eye health, resveratrol may be beneficial for the “wet” from of AMD, because that type involves damage to blood vessels and resveratrol has been shown to protect against blood vessel damage.

There is one zeaxanthin formula on the market that contains resveratrol and dozens of other antioxidants, too many to list here. But, most of the dietary supplements on the market are poorly designed. Testing has revealed that many cheap supplements do not contain what the label claims. This is one instance where you get what you pay for.

When you are comparing supplements, check out the manufacturer. Be sure that the company takes steps to insure purity, potency and effectiveness. Visit their website and read customer comments, if they post them. Look for a no risk guarantee.

Make sure that the zeaxanthin formula that you choose contains all natural ingredients. Many vitamins, including vitamin E, can be created synthetically for less money than it costs to buy the naturally occurring vitamin. Most of the supplements on the market contain the synthetic form.

Some scientists argue that synthetics are just as good as the naturally occurring nutrients. But, there have been no scientific studies comparing the activity of the synthetic types to the naturally occurring vitamins. It really doesn't make sense that a “plastic” vitamin would do your body any good.

More studies are being conducted every day concerning the benefits of antioxidants to human health. They all indicate that a zeaxanthin formula is a worthwhile investment, as long as it provides a number of different antixoidants.
Neovascular Age Related Macular Degeneration
This film screen in the back of the eye is called the retina. There is a small highly sensitive area within the retina that is called the macula. A disease called “age-related macular degeneration” or AMD is the most common cause of blindness among the elderly.

Within the central macula, zeaxanthin is the predominate pigment. The pigment in the surrounding retina is primarily lutein.

Zeaxanthin and lutein are in the carotenoid family, which also includes beta-carotene. Beta-carotene is converted within the body to vitamin A. Vitamin A is an essential nutrient. Insufficient intake causes a variety of diseases, starting with dry flaky skin and sometimes ending in blindness or death.

The other carotenoids are not (yet) considered essential, since there is no specific acute disease that is caused by their absence in the diet. However, there is growing evidence that many chronic, life-threatening and age-related diseases are caused by low intake of various carotenoids and other “micronutrients”.

Micronutrients are those that are present in many different foods, but only in small amounts. The roles that they play in the human body are not yet fully understood. Many health experts believe that these micronutrients are lacking in most people's diets, particularly the typical American diet.

Approximately 1.2 million Americans are affected by AMD. In a six year study, the National Eye Institute in Maryland found that lutein and zeaxanthin protect against blindness in those people that have AMD. Several studies indicate that the micronutrients reduce the risk of AMD, altogether.

There are several other risk factors, including family history. The lifetime risk of developing AMD is 50% among people who have or had a relative with the condition, versus 12% of people with no family history of the disease. Yet, even the family prevalence may be related to the body's ability to create specific nutrients.

For example, ATP is a nutrient that is not considered essential because, it is created within the cells of the human body. But, in people with a family history of AMD, there is often a mutated gene that interferes with the body's ability to synthesize or make ATP. ATP is the cell's energy. When ATP production is inadequate, cellular function is negatively affected.

High blood pressure, high cholesterol, obesity, high intake of dietary fat and oxidative stress all contribute to age-related macular degeneration. In the typical American diet 42% of the caloric intake is from fat. 30% should be the max and 20-25% is probably healthier.

But, regardless of how healthy your diet is, it is a relative impossibility to get all of the important micronutrients in quantities sufficient to protect your long-term health, without supplementation. Most experts recommend 50mg of lutein and 10 of zeaxanthin for daily supplementation.
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