Scientists at Bonn and D'sseldorf Universities investigated more than 500,000 positions in the human genome and found a gene variant which occurs clearly more repeatedly in bald men than in control individuals. This means they have found a novel hair loss gene, according to their transcription in Nature Genetics.
In 2005, these scientists had earlier characterized the first hair-loss gene inherited through the maternal line, which explained why hair-loss in men once more reflects that of their maternal grandfathers. This newly discovered gene, on the other hand, may now assess for the connection in cranial hair growth between father and son.
The researchers had concentrated their intentness on the genomes of just under 300 men suffering from considerable hair loss, investigating for this project over 500,000 alternating sites in the genomes of their test subjects. Two positions many times displayed a definite parallelism with baldness in these men a positive display that the genes located at those points were involved in hair loss.
In one of these well marked regions lies the gene for the androgen receptor, Dr. Axel Hillmer of the Life&Brain Forschungszentrum (research centre) in Bonn states. We had already learnt from an earlier study that this receptor was linked to hair loss. However, the other region was new to us.
This is only the second region of the genome that can definitely be correlative with early hair loss. We are now trying to discover the role played by this genomic region in hair growth, says Dr. Felix Brockschmidt of Bonn University. Only then will we know whether we on the right track for new forms of therapy for male hair loss.
The model was conducted by the research teams headed by Professor Dr. Markus N'then (Bonn University's Institute of Human Genetics and Life & Brain-Center) and Privatdozent Dr. Roland Kruse (Department of Dermatology, University Clinic D'sseldorf). Over a term of years, the scientists had collected blood samples from affected males all over Germany. As ramification of their investigation, they have been able to attest their findings with supplemental sufferers in Australia. The Australian research group is headed by Nicholas Martin (Queensland Institute of Medical Research, Brisbane).
hair loss genesThe results expose that more than one gene is entangled in the spread of male hair-loss. These results also import interesting light on the heredity of baldness in that hitherto the only known risk gene for the androgen receptor lay on the X-chromosome, and was thus inherited from the mother which accounts for the fact that in the case of hair-loss men often take after their maternal grandfathers. Yet, the newly discovered gene lies on chromosome 20, and can be hereditary from both the mother and the father.
This helps to provide an explanation for the similarity between father and son, declares Professor N'then.
The scientists conjecture that other genes are also involved in early hair-loss, and they are now looking for new volunteers to assist with this research. We are looking for men under 40 years of age who have advanced hair-loss, says Privatdozent Dr. Kruse. And we are also seeking men over 60 with a full head of hair as controls. All participants will receive expense allowances.
New Hair Loss Product
Whilst it may be comforting to know that humans are not alone in suffering hair loss (primates such as monkeys also experience thinning on their head) - understanding the causes of hair loss means we can take proactive action. Even though genetics does play a part, new research has uncovered a nutritional deficiency link in both men and women. And other factors, such as stress, and poor hair care, are well within our capacity to change.
The genetic link in hair loss has been well studied. It is associated with male and female pattern hair loss, or alopecia. In these individuals there is an increased sensitivity to the sex hormone, DHT. DHT stands for dihydrotestosterone, and is a powerful metabolite of testosterone. It contributes to men's unique gender characteristics, as well as facial and body hair, and the deepening of men's voices at puberty.
DHT causes the growth cycle of hair follicles to shorten, which in turn reduces the size of the hair shaft. Increasingly narrower hair is grown, sometimes as fine as fluff, and in more extreme cases, there is complete hair loss in that area.
In women, estrogen usually counteracts the effects of testosterone. But when women go through menopause, or suffer hormonal imbalances, the reduction in estrogen can lead to female pattern baldness. Fortunately, this is not as drastic in its hair loss effects as male pattern baldness. Instead the hair tends to thin, and the crown parting becomes wider.
But a very interesting study by L'Oreal has linked an iron deficiency to hair loss, in both men and women. This was a placebo controlled, double blind study in which 13,000 healthy men and women took a supplement, and had the ferritin (iron) levels in their blood measured and cross referenced with information on their hair loss.
The results showed not only a link between hair loss and iron deficiency, but they were able to estimate the risk of hair loss in a certain level of iron deficiency. For example, women whose blood ferritin levels dropped from a normal 70•?g/l to 40•?g/l, had a 28% higher chance of severe hair loss. The post menopausal women in the study who had severe hair loss all had much lower levels of iron than the women who didn't have severe hair loss.
The problem with iron supplementation, however, is that excess iron builds up in the body's tissues and becomes toxic. It has been associated with an increased risk of developing chronic illnesses. Iron levels can be tested by a doctor, so if hair loss is a concern, its best to get your iron levels tested first before taking iron supplements.
Other potential causes of hair loss - or at least, contributing factors are stress and poor hair care practices. Not brushing hair regularly, or washing it regularly, can affect the normal hair growth cycle.
When hair that is naturally at the end of its life cycle is removed through brushing, it allows another hair to grow underneath it. Regular brushing naturally removes dead hair that is ready to fall out. Not removing that hair means new growth cannot occur, as the old hair smothers the new growth. Dirt and oil build up can have a similar effect, so its important to wash hair regularly.
Stress can affect the circulation of nutrients and oxygen to the scalp, by causing the muscles in the scalp to tighten. If this happens over a long period of time, premature hair loss can occur. This cause of hair loss is distinct from male pattern baldness (which is hormonal), but it can certainly exacerbate the condition. And stress reduction techniques are simple things that can be added to a daily routine, to prevent hair loss, and improve the overall quality of life.
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