According to news reports from Science Daily, scientists developed a "five-biomarker panel that if commercially developed, may be useful when combined with a currently available test measuring a pancreatic-cancer biomarker called CA 19.9, which is elevated 80 percent of the time among newly diagnosed patients."
The study involved experts from the Hutchinson Cancer Research Center, Massachusetts General Hospital, University of Michigan and the Belfer Institute of Innovative Cancer Science at Dana-Faber Cancer Institute all of which collaborated on the findings revealing that the biomarkers among the study's test mice translated to similar biomarkers among humans.
This means that if the biomarkers among both the mice and humans are similar, the biomarkers will likely be able to increase early detection of the deadly pancreatic condition.
Because treatments are more effective during initial stages of this disease, this development of may revolutionize the detection of this and potentially other similar diseases, according to expert statements obtained from news reports.
Defining Pancreatic Cancer
The cancer develops in the tissues of the organ that commonly "regulates the metabolism of sugars," according to the Mayo Clinic. Unfortunately, the Mayo Clinic also reports that the conditionis often described as a "leading cause of cancer deaths? because it is not detected in its early stages and has a very poor prognosis.
According to Science Daily, pancreatic cancer is "the fourth leading cause of cancer death... with a five-year survival rate of only 3 percent." Additionally, if pancreatic solid tumors are caught in the early stages approximately 90 percent of the time they can be treated, whereas if the cancer is caught in later stages, treatment is successful only 10 percent of the time.
Each year more than 29,000 additional Americans are diagnosed with cancer of the pancreas, according to the National Cancer Institute (NCI), which also explained that pancreatic cancer is considered a "silent disease? because of the minimal and sometimes deceiving symptoms that are difficult to recognize and associate with pancreatic cancer. The NCI reported the following symptoms and signs of pancreatic cancer:
* weight loss
* nausea and vomiting
* weakness
* loss of appetite
* pain in upper back or abdomen
* dark urine from jaundice
* yellowing skin and eyes
Causes and Prescription Drug Dangers
According to the American Cancer Society (ACS) there are several risk factors associated with the development of pancreatic cancer, but researchers are still unsure as exactly what causes the condition. However, the following are common characterisitcs making an individual more likely to develop the condition, according to ACS:
* age
* gender
* race
* smoking
* diet, lack of exercises and obesity
* diabetes
* chronic pancreatitis
* cirrhosis of the liver
* work exposure to pesticides, dyes and chemicals
* family history, hereditary conditions
* gene changes/inherited gene mutations
* stomach problems/surplus of stomach acids
Unfortunately, there is also another risk factor that can be attributed to man-made circumstances including the consumption of prescription drugs, which may cause pancreatitis leading to pancreatic cancer. For example, a prescription type 2 diabetes drug known as Byetta (exenatide) has recently been linked to the onset of pancreatitis, which is inflammation of the pancreas, according to a U.S. Food and Drug Administration's (FDA) Health Advisory.
Byetta, from Eli Lilly and Amylin Pharmceuticals, was released in 2005 and by August 2008, six individuals consuming the drug had been hospitalized for pancreatitis conditions, two of whom died. There have also been 30 additional cases of acute pancreatitis, which is sudden pancreatic inflammation, allegedly associated with the drug's consumption.
Because Byetta-induced pancreatitis can potentially lead to a fatal pancreatic cancer it is imperative that an individual speak with a medical professional on the Byetta dangers as well as consider developing a Byetta class action lawsuit for the severe and irreversible side effects the drug may have already caused.
Signs Of Pancreatic Cancer
Stomach Pains
Among the basic pancreatic cancer symptoms is a soreness or pain in the high abdomen. Patients often complain that the pain spreads through the area and around to their back. Many people going through this type of discomfort will often experience alleviation once they lean forward.
This type of abdomen pain is usually present in the majority of patients (approximately 80%), but is typically only evident during the advance stages of the disease. Eating can often worsen the pain or cause increased discomfort.
Weight Loss
Loss of appetite and subsequent weight loss are also common symptoms associated with pancreatic cancer. Unfortunately, appetite loss and decreased weight are also symptoms associated with a number of other diseases and ailments, including digestive issues.
Painful or Painless Jaundice
Since pancreatic cancer can block the bile duct - which flows partly through the head of the pancreas - jaundice is a frequent symptom of the disease. Tumors that develop on the pancreas are typically the root of jaundice development, which is characterized by a yellowing of the skin.
Generally, those diagnosed with pancreatic cancer see jaundice companioned with orange or dark urine and constant itching of the skin. Roughly one-half of localized pancreatic cancer patients endure painful jaundice, while half of those with less advanced or treatable forms of the disease are diagnosed in the midst of painless jaundice.
Trusseau Sign
Trusseau Sign is a secondary or complex evidence where blood clots form in portal blood vessels, deep veins and superficial veins spontaneously. It is sometimes associated with or common to patients diagnosed with pancreatic cancer.
Clinical Depression
Though not as exhaustively accounted or referenced, depression is a subtle side effect of pancreatic cancer. The clinical depression often develops even before the disease is detected. Doctors and researchers are still unsure why or how the two connect.
How Pancreatic Cancer is Diagnosed
To properly diagnose pancreatic cancer, your doctor must either do a liver function test or check for certain markers, like CA19-9, which indicate the presence of pancreatic cancer when detected in high amounts. Most patients are not screened until the above symptoms are presented.
In addition, imaging such as ultrasounds and a CT scan on the abdomen can be done to identify potentially visible tumors. Some patients may require an endoscopic ultrasound to obtain tissue samples or see the tumor location.
Early Screening for Pancreatic Cancer
If you have two or more immediate family members (or three or more extended relatives) who have been diagnosed with pancreatic cancer symptoms, you should ask your doctor about early screening for the disease.
Pancreatic cancer symptoms often don't present themselves until it is too late, making early screening critical for those at risk. So any multiple incidents of signs described above should be evaluted by a trusted physician.
Both Peter Kent & Trevor Price are contributors for EditorialToday. The above articles have been edited for relevancy and timeliness. All write-ups, reviews, tips and guides published by EditorialToday.com and its partners or affiliates are for informational purposes only. They should not be used for any legal or any other type of advice. We do not endorse any author, contributor, writer or article posted by our team.
Peter Kent has sinced written about articles on various topics from Exhaust, Fitness and Health. LegalView () offers a plethora of legal topics for individuals in need, ranging from information on Byetta (. Peter Kent's top article generates over 40500 views. to your Favourites.
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