The knee is particularly vulnerable to injury and accidents due to its position in the leg, and injuries lead to pain, joint instability and loss of normal leg function. The initial part of the examination looks at the injury cause and the forces involved, how fast the knee effusion came up, the presence of joint instability on walking and whether the patient is unable to take normal body weight on the knee.
The amount of pain a patient suffers indicates the severity of the injury involved and the particular location of the pain can point to which anatomical structures have been injured. As the knee will be very difficult to walk on in the presence of a fracture these injuries are rarely missed in diagnosis. During the examination the physiotherapist will test the knee structures to look for the cause of the injury.
Objective Examination of the Knee
Knee effusion or joint swelling is an indication of the degree of inflammation present in the knee and the physio will check the amount of swelling manually. If the swelling is severe it can be drained using needle aspiration to relieve the pressure which can interfere with normal muscle recruitment and function. The physio records the movements of the knee on the plinth non weight bearing, assessing straightening and bending of the knee (extension and flexion) and the small degrees of rotation.
The patient is asked to move the knee and the physio judges how keen they are to move in the presence of pain, indicating where rehab needs to be started. Once the active range (what the patient does for themselves) is known the physiotherapist may try and push the joint a bit further to see if there is a problem or just guarding. Muscle testing of the quadriceps muscle for knee extension and the hamstring muscles for knee flexion inform the physio about the state of the muscles and how much strength the patient can exert without too much pain.
Stability is confirmed on a mechanically unstable joint by the ligaments and muscles. Physiotherapy testing of the collateral ligaments of the knee, the medial and lateral ligaments, is done by stressing the knee into knock-knee and bow-leg. These ligaments provide side-to-side stability to the knee. The anterior cruciate ligament and the posterior cruciate ligament are tested in the same way, giving front to back and rotatory stability to the joint. The joint structures are then palpated by the physio to confirm the diagnosis.
Physiotherapy treatment plan
An acutely painful knee is treated using the PRICE technique, starting with protection of the joint if necessary by using a brace to stabilise it. Crutches or sticks can be used to reduce weight bearing on the knee and allow a good walking pattern. Ice treatment, or cryotherapy, is a first line treatment for an acute knee, reducing pain and the swelling which permits increased movement and progression of treatment. A neoprene knee sleeve may be worn to squeeze the swelling and increase stability.
A reduction in swelling and pain allows the physiotherapist to give exercises to improve the knee's ranges of movement and strength. The largest and most powerful muscles are the quadriceps and the hamstrings. The quadriceps allows knee power for getting up from sitting, going up and down stairs and walking, keeping the knee stable. After the knee copes with exercise on the plinth the physio will move to exercises in weight-bearing and in more active activities.
Proprioception is the body's natural joint position sense, with the brain sensing the moment to moment position changes of the knee and co-coordinating the muscle actions needed keep the joint within safe bounds. Physio treatment is balance practice, starting with standing on one leg, then balancing and catching balls on a wobble board and finishing with running, changing direction suddenly, hopping and jumping. Once the swelling has settled and the strength and co-ordination ability restored the knee is ready to rejoin normal and sporting activities.
Treatment Of Knee Osteoarthritis
While this proclamation will hinder the development of some therapies in medicine, it should not be a major stumbling block in the management of osteoarthritis.
The reason?
Current approaches using stem cells for osteoarthritis are able to make use of autologous stem cells. These are stem cells obtained from the iliac crest (hip) of the patient using a special biopsy needle.
Stem cells are located within the bone marrow. The iliac crest is an ideal site for harvesting bone marrow. Since the procedure is done using local anesthetic, the risks of the procedure are minimal.
Autologous stem cells have the ability to differentiate into other tissue cells. Previously, it was felt this trait was not possible for adult stem cells; however, it has been confirmed that stem cells harvested from an adult are capable of differentiation.
Once the stem cells are harvested, they are concentrated using a special technique. In addition, platelet rich plasma which is derived from a patient's whole blood is also obtained. Platelets are cells that contain numerous growth and healing properties. These growth factors have the ability to fire off tyrosine kinase receptors on the surface of stem cells and accelerate differentiation and multiplication.
The knee (or hip) is then prepared by “irritating” the cartilage using a special biopsy needle. After this, stem cells and platelet rich plasma are introduced into the joint.
Calcium chloride and thrombin are also used to create a “scaffold” for the stem cells to locate themselves.
Diagnostic ultrasound is used throughout to ensure the proper location for harvesting the stem cells as well as the best location for introducing the stem cells into the target joint. The use of ultrasound is mandatory for proper anatomic placement!
So who might be a candidate for this procedure?
First, it's important to realize that a patient must have some cartilage remaining in the knee for stem cells to do their job.
Osteoarthritis is currently graded in clinical trials using standing knee x-rays to quantify the amount of cartilage present within the knee.
The Kellgren-Lawrence classification is used. Grade 1 means the amount of cartilage is relatively normal. Stage 4 means that the patient is “bone on bone”. Patients who are Kellgren- Lawrence stage 4 are not considered candidates for stem cell treatment. Patients who are grades 1-3 are acceptable.
Patients who are grade 3 must be at or near ideal weight.
Age also plays a role. It appears that as people get older, their stem cells respond less to stem cell stimulation. At our center, we generally use 75 as the cutoff. Even then the patient must be vigorous and active.
The ideal patient is between the ages of 30-70 and is at or near ideal weight. Healthy Baby Boomers who are athletic and active are felt to be the best candidates.
What measures are assessed?
We are currently evaluating both subjective as well as objective parameters. These include a visual analogue scale of pain, a Health Assessment Questionnaire (WOMAC), 50 foot walking time, knee x-rays done using special angulation to allow precise measurements of cartilage thickness, and ultrasound measurements of cartilage thickness.
The length of recovery is highly variable depending on factors such as age, general physical condition, Kellgren-Lawrence stage, and amount of “irritation” required to prepare the cartilage.
For more information regarding stem cells for osteoarthritis, call the Arthritis and Osteoporosis Center of Maryland at (301) 694-5800.
Both Jonathan Blood-smyth & Nathan Wei are contributors for EditorialToday. The above articles have been edited for relevancy and timeliness. All write-ups, reviews, tips and guides published by EditorialToday.com and its partners or affiliates are for informational purposes only. They should not be used for any legal or any other type of advice. We do not endorse any author, contributor, writer or article posted by our team.
Jonathan Blood-smyth has sinced written about articles on various topics from Health, Physical Therapy and Health. Jonathan Blood Smyth is a Superintendent at an NHS hospital in the South-West of the UK. He specialises in orthopaedic conditions and looking a. Jonathan Blood-smyth's top article generates over 3600 views. to your Favourites.
Nathan Wei has sinced written about articles on various topics from Arthritis Pain, Health and Arthritis Signs. Nathan Wei, MD FACP FACR is a nationally known board-certified rheumatologist. For more info: an. Nathan Wei's top article generates over 550000 views. to your Favourites.
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