Thyroid cancer is an affection of the thyroid gland. It is known that this curable cancer may be treated only with surgical removal of at least a part of the thyroid gland. This surgical intervention needs to be followed by RAI. A lifelong T4 treatment is recommended to hold back serum TSH. With less chances of curing we might mention histological thyroid cancer such as undifferentiated thyroid cancer, medullary thyroid cancer and follicular thyroid cancer. Invasive tumor and old age also represent along with tumors larger than 5 cm poor prognostic factors in thyroid cancer.
It is not a general opinion that says subtotal or complete thyroidectomy in absolutely necessary in treating thyroid cancer. More than that most of the specialists believe that partial thyroidectomy or lumpectomy is a poor operation.
These different opinions about treating patients with thyroid cancer are the results of many medical reports that say papillary thyroid cancer, for example, will be cured well in more than 80 % of the cases in spite of how they are treated.
Regardless to all different opinions we may say that total thyroidectomy has advantages too. Total thyroidectomy means the removal of all intrathyroid tumors and the ability to follow up with thyroglobulin.
After surgical treatment of any type of thyroid cancer a decision about ablating or not any remaining tissue must be taken.
Some categories of patients such as patients that have passed 40 years, patients with follicular cancer, patients with occult papillary cancer, patients under 20 with the same types of cancer and patients of any age with residual tumor or in metastatic phases are highly recommended for an ablative dose of l-131. Contrarily to the categories of patients mentioned earlier, patients with medullary and anaplastic cancers do not concentrate l-131 therefore there is no need for ablation.
Ablation treatment is recommended is indicated to be taken for at least four weeks after ending T3 and T4 treatments in order to increase l-131 intake. If this method fails the patient is advised for thyroid hormone therapy. This way of treatment should hold back serum TSH to reach undetectable levels. Another scan is not necessary if the ablation proves to be a success or if thyroglobulin level is normal and recurrent disease does not mean a risk. I-131 ablation is the choice for metastatic thyroid cancer too because chemotherapy proved to be inefficient.
One of the biggest concerns of the patients is the cosmetic appearance after an intervention. Treatment is not going to reduce significantly the size of the goiter and neither the surgical intervention. More than that, a surgical intervention never proved to be unaesthetic.
Treatment Of Thyroid Cancer
According to the latest experimental studies, heath physicists have encountered safe methods to use a radioactive protein found in scorpion venom to treat thyroid cancer. The venom of a yellow species of scorpions found in Israel is promising to develop into a revolutionary technique to fight different types of tissues affected by cancer.
The Transmolecular Corporation in Cambridge has successfully obtained in the laboratory a radioactive variant of the venom protein. The new substance is called TM-601 and consists of the radioactive substance Iodine-131 and an artificially obtained venom protein. When the artificial compound is released into the blood, the radioactive waves kill the foreign, cancer cells.
Every year, about 17000 persons suffer from this type of cancer and many of them die within the first months of treatment. The new technique promises a remission of the cancer within the first months, after the radioactive compound has been injected into the body. The patient will require no further chemotherapy or traditional therapeutically radiations. The procedure promises a good improvement of the cancer symptoms and a high rate of surviving.
The phase two of the human trial using the new compound shows safe ways of handling the new treatment, even by injecting higher doses of radiations into the cells than during the first stage experiments.
The physician's duty is to release on the medical market a both safe and legal product with a high index of success. The doctors prescribing this therapy must also protect the family members and the environment of the patient from the radioactivity of the drug.
During the human testing, a group of several patients receive the medication three times within three weeks, while another group gets the therapy six times in six weeks. All patients receive the same quantity of medicine, meaning 200 MCI in the treatment of thyroid cancer. The results are satisfactory compared to other types of therapy used before.
Research scientists discovered that TM-601 is not being assimilated by other tissues besides the cancer cells. The tissue parts near the tumor also receive an amount of radiation but in a lower rate. Before the treatment, patients are administered with high doses of non-radioactive iodine to prevent the assimilation of the drug by the absorbing thyroid, to block the uptake of Iodine-131. The thyroid gland quickly absorbs iodine in normal circumstances.
A part of the radiations received during the treatment are transmitted by the patient's body to the family members in the first hours after returning from the hospital. However, studies show that the level of radioactive waves spread by the body is not larger than the ones reflected after traditional radioactive therapy.
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