Mitoxantrone has been used in the past for prostate cancer and leukemia but latest research proved its immunosuppressant character and thus, its efficiency in dealing with MS. By reducing the activity of the immune system, mitoxantrone slows the activity of MS and decreases the frequency of relapses.
The treatment with this medicine once every three months and a complete treatment may get to three years. FDA doesn't recommend a too large total amount because it damages the heart. Mitoxantrone was approved by the FDA to treat three forms of progressive MS: secondary - progressive MS, progressing - relapsing MS and advanced relapsing - remitted MS.
There are only two medicines that can deal with progressive MS. One of them is betaseron, mitoxantrone - the other. The first one is to be preferred because it doesn't affect the heart like mitoxantrone does. It is recommended though, in case you can't tolerate betaseron.
Mitoxantrone decreases the number of attack and lesions of the brain and spinal cord and slows the progress of MS in people with secondary - progressive MS and also the other types.
The side effects of mitoxantrone include very severe damage of the heart, even little cases. The heart should be permanently monitored, and the doses decreased so that it causes less harm to this vital organ. 12 doses are recommended: one every three months, for about three years.
Other side effects include:
* - Nausea
* - Hair loss
* - Changes of the menstrual cycles in women
* - Diarrhea or constipation
* - Increased risks of UTI and other infections
* - Mouth sores
Because of the severe side effects, this medicine tends to be used more in specialized clinics for MS under the strict supervisions of neurologists and other specialists.
As it is also the case with interferon beta, mitoxantrone treatment should include frequent tests of blood to determine whether the number of leukocytes is normal and the liver functions properly.
It is not recommended during pregnancy, in case of heart conditions, liver or blood disorders because it may increase the complications.
Treatments For Multiple Sclerosis
AIDS, lupus, arteritis, hereditary ataxias, Guillain-Barr?? syndrome, Lyme disease, a cyst in the spinal cord are the diseases with which differential diagnosis must be done so as to clarify the diagnosis of multiple sclerosis. To perform various tests samples of cerebrospinal fluid are needed. In multiple sclerosis the antibodies concentration in the cerebrospinal fluid is high, the white blood cell count and protein content of the fluid may be higher. MRI or magnetic resonance imaging is the best procedure to detect multiple sclerosis and confirms the diagnosis, helps detecting the areas of active inflammation and demyelination.
In multiple sclerosis the brain???s response to the stimuli such as: flashing lights and other sensory stimuli are slow because of the interrupted conduction through demyelinated nerve fibers.
Treatment
Early treatment is very important because the brain is not damaged entirely and physical disability can be slowed in its progression. Learn from your doctor about optional therapies and any possible ways of getting your life improved.
The most used treatment in multiple sclerosis were corticosteroids, for example Meticorten. But they do not stop the progression of the disability. For people who have affected the optic nerve corticosteroids are given intravenously. If used for a long time corticosteroids have many side effects such as: ulcers, weight gain, diabetes, fatigue, decreased bone density. Other treatments are: interferon-beta Betaseron injections, Rebif, Avonex that reduce the frequency relapses and help prevent the later disability.
There are available the following products: acetate injections Copaxone, Novantrone which can reduce the relapses and the progression of the disease. Interferons and gamma globulins interviene in the distruction of the myelin and destroy the abnormal antibodies. For relieving the pain propanolol is used. To reduce the tremor doctors prescribe Inderal, Symmetrel to relieve the fatigue, to treat depression Endep, Elavil and Zoloft.
It is important to maintain an active lifestyle with physical exercises such as: riding a stationary bicycle, swimming, walking, stretching that reduces spasticity and maintain a muscular, cardiovascular, psychologic health. Do not expose yourself at high temperatures and do not have hot baths or showers. In choosing a multiple sclerosis treatment one should consider effectiveness, side effects and convenience because multiple sclerosis is a long life disease. Ask your doctor about the risks and benefits your treatment provides you safety, side effects, ease of use.
Changes in your life style have great effect, in treating multiple sclerosis so try to exercise, keep a diet.
Both Tobias Higgens & Groshan Fabiola are contributors for EditorialToday. The above articles have been edited for relevancy and timeliness. All write-ups, reviews, tips and guides published by EditorialToday.com and its partners or affiliates are for informational purposes only. They should not be used for any legal or any other type of advice. We do not endorse any author, contributor, writer or article posted by our team.
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