The right blog makes a big difference. If you want to set yourself apart, I recommend creating a custom blog solution - one that can be completely customized to your users. In most cases, WordPress, Blogger, MovableType or Typepad will suffice, but building from scratch allows you to be very creative with functionality and formatting. Think about how you want comments, archiving, sub-pages, categorization, multiple feeds and user accounts to operate in order to narrow down your choices.
Host Your Blog Directly on Your Domain
Hosting your blog on a different domain from your primary site is one of the worst mistakes you can make. A blog on your domain can attract links, attention, publicity, trust and search rankings - by keeping the blog on a separate domain, you shoot yourself in the foot.
Write Title Tags with Two Audiences in Mind
First and foremost, you're writing a title tag for the people who will visit your site or have a subscription to your feed. Title tags which are short, snappy, on-topic and catchy are imperative. You also want to think about search engines when you title your posts, since the engines can help to drive traffic to your blog. A great way to do this is to write the post and the title first, then run a few searches at Overture, WordTracker & KeywordDiscovery to see if there is a phrasing or ordering that can better help you to target "searched for" terms.
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Participate at Related Forums & Blogs
Irrespective of the industry or niche you're in, there are bloggers, forums and an online community that's already active. Depending on the specificity of your focus, you may need to think one or two levels broader than your own content to find a large community, but with the size of the participatory web today, even the highly specialized content areas receive attention. A great way to find out who these people are is to use Technorati to conduct searches, and then sort by number of links (authority). Del.icio.us tags are also very useful in this process, as are straight searches at the engines (Ask.com's blog search in particular is of very good quality).
Tag Your Content
Technorati is the first place that you should be tagging posts. I actually recommend having the tags right on your page, pointing to the Technorati searches that you're targeting. There are other good places to ping - del.icio.us and Flickr being the two most obvious (the only other one is Blogmarks, which is much smaller). Tagging content can also be valuable to help give you a "bump" towards getting traffic from big sites like Reddit, Digg & StumbleUpon (which requires that you download the toolbar, but trust me - it's worth it).
Launch Without Comments (and Add Them Later)
There's something sad about a blog with 0 comments on every post. It feels dead, empty and unpopular. Luckily, there's an easy solution - don't offer the ability to post comments on the blog and no one will know that you only get 20 uniques a day. Once you're upwards of 100 RSS subscribers and/or 750 unique visitors per day, you can open up the comments and see light activity. Comments are often how tech-savvy new visitors judge the popularity of a site (and thus, its worth), so play to your strengths and keep your obscurity private.
Don't Jump on the Bandwagon
Some memes are worthy of being talked about by every blogger in the space, but most aren't. Just because there's huge news in your industry or niche DOES NOT mean you need to be covering it, or even mentioning it (though it can be valuable to link to it as an aside, just to integrate a shared experience into your unique content). Many of the best blogs online DO talk about the big trends - this is because they're already popular, established and is counted on to be a source of news for the community. If you're launching a new blog, you need to show people in your space that you can offer something unique, different and valuable - not just the same story from your point of view.
Link Intelligently
When you link out in your blog posts, use convention where applicable and creativity when warranted, but be aware of how the links you serve are part of the content you provide. Not every issue you discuss or site you mention needs a link, but there's a fine line between overlinking and underlinking. The best advice I can give is to think of the post from the standpoint of a relatively uninformed reader. If you mention Wikipedia, everyone is familiar and no link is required. If you mention a specific page at Wikipedia, a link is necessary and important. Also, be aware that quoting other bloggers or online sources (or even discussing their ideas) without linking to them is considered bad etiquettes and can earn you scorn that could cost you links from those sources in the future. It's almost always better to be over-generous with links than under-generous. And link condoms? Only use them when you're linking to something you find truly distasteful or have serious apprehension about.