Fans of the Fox television crime drama series have a lot to look forward to in season 3, according to cast member Dominic Purcell, who stars as wrongfully accused felon Lincoln Burrows. He has stated that the show is attempting a back-to-basics approach by setting much of the action within another prison, similar to the setting and premise of the first season. Lincoln's brother Michael Scofield, played by Wentworth Miller, is forced to contend with an out-of-control prison system in Panama. The new jail is devoid of any law system or order, with inmates being left to fend for themselves and where only the strongest survive.

Purcell has stated that he believes the new season to be the best one yet, and in addition, his fellow cast member Amaury Nolasco also said that season 3 has really pushed the envelope for the series. But compared to Purcell's frank openness and candid answers to questions about the third season, Nolasco provided more mysterious and cryptic tidbits about what's to come. In the previous season, Nolasco's character Fernando Sucre suffered a notable number of setbacks and problems. Among these were being stabbed by the serial killer T-Bag, played by Robert Knepper, and the heinous abduction of his lover Maricruz Delgado, played by Camille Guaty.

Giving more details, Nolasco said that numerous loose ends and subplots were going to be tied up, such as Sucre's search for his girlfriend. While remaining mum on more specific details, he also stated there was a chance that some of the material they filmed might not be allowed to be shown on national television, due to possible extreme content. However, he said that what the series has done yet again this season is to reinvent itself with its latest developments, and that fans should look forward to that.