Compositions, and methods of use thereof, are provided for the prevention or treatment of side effects associated with the use of drugs that act as 5HT2/5HT3 serotonin receptor antagonists and alpha-2 adrenergic receptor antagonists (5HT2/5HT3 antagonist/alpha-2 antagonist). The method involves using dopamine-releasing compounds, such as amantadine, anticonvulsants, such as zonisamide, or dopamine/norepinephrine reuptake inhibitors, such as bupropion, in combination with 5HT2/5HT3 antagonist/alpha-2 antagonists, such as mirtazapine, to reduce the excessive daytime drowsiness and/or weight gain associated with 5HT2/5HT3 antagonist/alpha-2 antagonist use for the treatment of disorders, such as, depression, schizophrenia, anxiety disorders, sleep-related breathing disorders, insomnia, migraine headache, chronic tension-type headache, hot flashes, lower back pain, neuropathic pain and functional somatic syndromes. Formulations of dopamine-releasing compounds or anticonvulsants with 5HT2/5HT3 antagonist/alpha-2 antagonists are provided. In particular embodiments, combination therapy with mirtazapine and zonisamide provides relief from chronic low back pain, while reducing or avoiding side effects associated with monotherapy with mirtazapine or zonisamide.

A device is disclosed usable for low level laser therapy to induce a photochemical reaction (non-heating) which is used in the treatment of conditions like tendonitis and other soft tissue injuries, wound healing and pain relief. The arrangement proposed will allow the device to be a Class I laser device thus providing long term minimization of the running costs of the device. The device includes a laser generating means ( 10 ) for generating a laser beam ( 14 ), the laser generating means ( 10 ) having an apparent source size and homogenising means ( 12 ) for modifying the laser beam ( 14 ) for modifying the apparent source size of the laser beam ( 14 ).

FIELD: medical equipment. ^ SUBSTANCE: device can be used for therapeutic non-invasive influence onto skin covers by electric pulses by means of described multiplicity of electrodes to make general effect onto physiological systems of human organism within wide range of pathological changes and to achieve pain-relief result. Device for electric stimulation has processor unit, power unit, power control unit 3, feedback signal analyzing unit 4, output unit 5, control switch unit 8, output signal indication unit 7, sonic indication unit 10 and interface unit 12 for computer. Device has the following units brought additionally: controlled electrode unit 6, visual indication unit 9 and extended control 11. Algorithms of automated selection of areas of through-skin electric stimulation and therapeutic session are used. Parameters of stimulation pulses can be chosen not only by doctor but by patient involved as well. ^ EFFECT: widened functional abilities; improved therapeutic effect; optimized procedure of therapy.

The present invention provides a method and devices for the treatment of hemorrhoids. The method involves the combined delivery of cryotherapy and medication therapy. The devices described provide cryotherapy for immediate relief of pain, itching, reduction of swelling, reduction of existing bleeding, shrinkage of hemorrhoidal tissue, and promotes healing of affective tissues. Subsequent medication release from these devices provides sustained healing and protracted relief of symptoms. The devices may be disposable and may be used externally or internally, and may include an invasive or non-invasive applicator.