How Sleep Affects Manic Depression Researchers have long studied the relationship between bipolar disorder and sleep in manic depressive patients. The intense manic and depression episodes clearly impact the quality of sleep and the amount of sleep that the bipolar person receives on a nightly basis.What many researchers have discovered as well is that the manic/depressive cycle works both ways. In other words, a lack of sleep can...... Similar Editorial : by Michael G. Rayel, MD. | Source : Bipolar Anxiety Depression