Diabetes insipidus has been sometimes called "stupid diabetes" because, although it has the name, it doesn't have the life-threatening problems of diabetes mellitus (sugar diabetes). Although you are not in risk for shock or diabetic coma, you are in for a very uncomfortable time. Diabetes insipidus doesn't go away on its own and does need medical attention...as soon as you get out of the bathroom. Please do not use this article as a substitution for a doctor's visit.
With diabetes insipidus, an important hormone with an incredibly unpronounceable name is suddenly ignored (or not made) by your body. This hormone, however, helps the body to absorb water from the kidneys and decrease your urine output. Since you are mostly made of water, it is important to be properly hydrated to keep alert and healthy. When your body is running low on water, it goes into dehydration pains in an attempt to force you to drink more water, fruit juice or herbal tea. However, since the kidneys can't absorb the water you are drinking, it just goes right out of you instead of to the rest of your body. This leaves you with an insatiable thirst and constantly screaming bladder. You might even wet the bed, no matter what your age. You won't be able to help it. And, sadly enough, you cannot drink enough water to satisfy your body. You could be drinking gallons of water a day and still become dehydrated.
Becoming dehydrated is very dangerous, as well as very painful. You become easily confused, can't make the simplest of decisions and will look to others like you are incredibly drunk. The odds of getting into accidents are really high when you are dehydrated. If someone pinches your hand and tells you to go to the hospital, just go. They have checked to see if your skin has enough moisture to bounce back immediately when pinched. If it still stays in a tent-like formation, then you are in big trouble.
DI should not be confused with diabetes mellitus, which results from insulin deficiency or resistance leading to high blood glucose. Diabetes insipidus and diabetes mellitus are unrelated, although they can have similar signs and symptoms, like excessive thirst and excessive urination.
Diabetes mellitus (DM) is far more common than DI and receives more news coverage. DM has two forms, referred to as type 1 diabetes (formerly called juvenile diabetes, or insulin-dependent diabetes mellitus, or IDDM) and type 2 diabetes (formerly called adult-onset diabetes, or noninsulin-dependent diabetes mellitus, or NIDDM). DI is a different form of illness altogether. Because DM is more common and because DM and DI have similar symptoms, a health care provider may suspect that a patient with DI has DM. But testing should make the diagnosis clear. Your physician must determine which type of DI is involved before proper treatment can begin. Diagnosis is based on a series of tests, including urinalysis and a fluid deprivation test.
Urinalysis is the physical and chemical examination of urine. The urine of a person with DI will be less concentrated. Therefore, the salt and waste concentrations are low, and the amount of water excreted is high. A physician evaluates the concentration of urine by measuring how many particles are in a kilogram of water (osmolality) or by comparing the weight of the urine to an equal volume of distilled water (specific gravity). A fluid deprivation test helps determine whether DI is caused by excessive intake of fluid, a defect in ADH production, or a defect in the kidneys' response to ADH. This test measures changes in body weight, urine output, and urine composition when fluids are withheld. Sometimes measuring blood levels of ADH during this test is also necessary.
Diabetes insipidus happens to men more than women; no one is entirely sure why. You could have diabetes insipidus because of a tumor or other growth which needs to be dealt with. You can even get it after seeming to recover from a serious illness like menegitis or a head injury. Other causes seemed to have included complications during pregnancy and a result of kidney malfunctions.
Diabetes Insipidus In Children
Diabetes insipidus (DI) are a disorder of which there an abnormal increase of urine output, liquid prerecording is frequently and thirst. It is caused by a deficiency of antidiuretic hormone, also known as vasopressin, or by an insensitivity of the kidneys to that hormone. It can also be induced iatrogenically by the diuretic conivaptan. Antidiuretic hormone is a hormone produced in a region of the brain called the hypothalamus. It is then stored and released from the pituitary gland, a small gland at the base of the brain. Central diabetes insipidus is caused by damage to the hypothalamus or pituitary gland as a result of surgery, infection, tumor, or head injury. Nephrogenic DI may occur as an inherited disorder in which male children receive the abnormal gene that causes the disease on the X chromosome from their mothers. It may also be caused by kidney disease, high levels of calcium in the body, and certain drugs.
Diabetes insipidus can also occur when kidneys are unable to properly respond to the hormone.When diabetes insipidus is caused by failure of the kidneys to respond to antidiuretic hormone, the condition is called nephrogenic diabetes insipidus. Adults with untreated diabetes insipidus may remain healthy for decades as long as enough water is drunk to offset the urinary losses. However, there is a continuous risk of dehydration. Diabetes insipidus and diabetes mellitus are unrelated, although they can have similar signs and symptoms, like excessive thirst and excessive urination. Patients with diabetes insipidus also must take special precautions, such as when traveling, to be prepared to treat vomiting or diarrhea and to avoid dehydration with exertion or hot weather. Diabetes insipidus can be treated by correcting the amount of urine that is produced by the body, although the condition usually requires life-long treatment.
Diabetes insipidus should not confuse with diabetes mellitus, the cause lacks or the resistance to the insulin causes the high blood glucose. Diabetes insipidus is characterized by excretion of large amounts of severely diluted urine, which cannot be reduced when fluid intake is reduced. It denotes inability of the kidney to concentrate urine. Symptoms of diabetes insipidus are quite similar to those of untreated diabetes mellitus, with the distinction that the urine is not sweet as it does not contain glucose and there is no hyperglycemia. Blurred vision is a rarity. In children, diabetes insipidus can interfere with appetite, eating, weight gain, and growth as well. They may present with fever, vomiting, or diarrhea. If the diabetes insipidus is due to renal pathology, desmopressin does not change either urine output or osmolarity.
The cause of the underlying condition should be treated when possible. Habit drinking is the most common imitator of diabetes insipidus at all ages. While many adult cases in the medical literature are associated with mental disorders, most patients with habit polydipsia have no other detectable disease. Central diabetes insipidus may be controlled with vasopressin. Vasopressin is administered as either a nasal spray or tablets. Vasopressin is ineffective for patients with nephrogenic DI. In most cases, if nephrogenic diabetes insipidus is caused by medication, stopping the medication leads to recovery of normal kidney function. Because pituitary DI is sometimes associated with abnormalities in other pituitary hormones, tests and sometimes treatments for these other abnormalities are also needed. Drugs used to treat nephrogenic DI include the anti-inflammatory medication indomethacin and the diuretics hydrochlorothiazide and amiloride.
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