OA is a disease of weight-bearing joints such as the neck, low back, hips, and knees.
Because the ability to ambulate depends entirely on properly functioning legs, the impact of OA on the hips and knees cannot be discounted. In fact, it has been estimated that more than 100,000 Americans cannot walk independently from their bed to the bathroom.
The focus of treatment for this disease has been primarily on pain relief and lifestyle changes. Proper weight management, exercise, physical therapy, and non-steroidal anti-inflammatory drugs have been the mainstays of treatment. For patients with more severe problems, injections of corticosteroids ("cortisone") and viscosupplements have also been used.
Unfortunately, these measures, while temporizing, aid in symptom control only. There have been no treatments that have been shown conclusively to regenerate cartilage and to heal damaged cartilage.
Glucosamine and chondroitin preparations have demonstrated a modest effects in the maintenance of cartilage... but studies have demonstrated conflicting evidence in regards to the quantity of improvement.
Recently, though, there has been increased interest in the use of stem cells as a possible treatment modality for this disease.
The use of fetal stem cells is highly controversial... however, there is another good source that escapes the controversy- adult stem cells.
So what are stem cells? They are progenitor cells, meaning they are the earliest form of cell. Stem cells (SC) are manufactured in the bone marrow and are pluropotential. This means they can differentiate into any kind of tissue cell. Stem cells are responsible for growth and healing in the body.
The adult type is embryo-free and can create a specific body part, such as tissue, cartilage and bone.
So how are adult stem cells obtained? According to Dr. Nathan Wei, "Adult stem cells are harvested from the posterior iliac crest of the pelvis (the back of the pelvis. Using local anesthetic with ultrasound guidance, a small biopsy needle is introduced. A syringe is connected to the needle and is used to remove stem cells from the bone marrow." Dr. Wei goes on to say, "The stem cells are then prepared and concentrated using a technique involving a specially designed centrifuge."
"At the same time we also draw blood from the patient in order to isolate platelet rich plasma. This platelet rich plasma contains specific growth factors that promote the regeneration of collagen, a major constituent of cartilage," he adds.
He goes on to say, "We then will enter the knee with another small needle using local anesthetic and "tease" the cartilage and the tendons that are the source of the arthritis ... as well as the source of much of the pain- all under ultrasound guidance. When we're done we'll inject the stem cells and the platelet rich plasma. The end result is cartilage regeneration."
According to most experts, potential side-effects are minimal. "Most patients are surprised at how quickly they are active again. The advantage of stem cell therapy is that it's like getting a new set of tires. Unlike getting a knee replacement, you can go back to aerobics and running, Dr. Wei states."
Dr. Wei says, "The advantage is that the patient is their own donor and provides their own therapy. It's a lot like getting a blood transfusion for yourself."
Because the cells aren't foreign to the body, engineered or manipulated in any way, there's no chance for contamination or rejection when the isolated cells re-enter the body.
Dr. Wei did offer a caveat. "The procedure is best for patients in the 30-60 year age range. When patients are older, their chondrocytes- cartilage cells- don't respond as well to stimulation by the stem cells and platelet rich plasma."
Stem Cell Treatment For Diabetes
For years mesothelioma cancer victims have suffered with no reprieve from their condition, caused by inhalation of asbestos fibers. However, victims received a glimmer of hope as scientists publish a study detailing a potential treatment of cancerous cells. The study, released in May 2008 in the Journal of Translational Medicine, exposed a weakness of the cancerous cells when treated to nonsteroidal anti-inflammatory drugs (NSAIDs), which many know as anti-inflammatory drugs like aspirin. Scientists combined the NSAIDs with Piroxicam and cisplatin (CDDP) and used the drugs to treat mesothelioma cells. The results were astounding as the treatment actually caused an anti-tumoral effect.
While this study offers a slice of hope for victims, the further research is required. Scientists with this study also found that the potential for determining a specific molecular target of mesothelioma cells, because of these drugs' anti-tumor effects, could lead to advances in therapy treatments of the deadly cancer.
What is Malignant Mesothelioma Cancer?
There are several varieties of mesothelioma cancer, however, malignant mesothelioma is considered one of the most lethal. It has been determined that malignant mesothelioma victims often have a median survival of only a few months in both untreated and treated cases, according to the study." Malignant mesothelioma is a rare cancer with malignant cancer cells forming on the sac lining of the chest or abdomen, according to the National Cancer Institute (NCI). It is often associated with exposure to airborne asbestos particles and fibers, which increases the risk of malignant mesothelioma developing in an individual.
Signs and Symptoms of Malignant Mesothelioma
Malignant mesothelioma is often marked by several symptoms including lumps in abdomen, weight loss, pain or swelling in the abdomen, pain under the rib cage and difficulties breathing. The cancer can also often cause fluid retention in the abdomen or around the lungs. The cancer often has symptoms similar to other conditions making misdiagnosis of the condition common.
Medical professionals have even admitted that malignant mesothelioma and lung cancer are very similar and differentiating between the two is difficult, however, there is an array of tests that physicians can use to increase the potential for a more accurate diagnosis. Tests for diagnosis may include the patient enduring physical exams, chest x-rays, biopsy of body tissues, getting a complete blood count (CBC), cytologic exam, which is an exam of cells under a microscope, or a bronchoscopy procedure where a bronchoscope is inserted into the nose or mouth for a better view of airways.
Diagnosing and Treating Malignant Mesothelioma
While treatments for mesothelioma are rare in and of themselves, it becomes increasingly difficult to treat malignant mesothelioma because of the severity of the condition. Factoring in the best method of treatment often depends on several factors. The following is a detailed list of these factors, according to the NCI:
* The stage of cancer, which includes stage I or localized malignant mesothelioma or advanced malignant mesothelioma that includes stage II, stage III and stage IV.
* The size of a tumor.
* Potential for tumor removal through a surgical procedure.
* The amount of fluid gathered in the chest or abdomen.
* A victim's age, physical health and previous health issues.
* Type of mesothelioma cancer.
* Whether a cancer is diagnosed as reoccurring or not.
Often, cancer may spread through the lymph system, blood stream or other bodily tissues.
Treatments for malignant mesothelioma can range from surgery to therapy, including chemotherapy and biological therapy to clinical trials, although the outcome is based on the progression of the cancer and most often, individuals are not aware of their condition until it reaches an advanced and, usually, an untreatable stage.
Asbestos Exposure and What to Do
Asbestos is a mineral fiber that was used heavily in a range of building materials from vinyl flooring to insulation. It was prized for its inexpensive production costs and fire-retardant ability making it ideal among construction companies. Unfortunately, the inhalation of high levels of asbestos dust and fibers contributed to the development of mesothelioma cancer.
Unfortunately, this discovery came far too late, as millions of Americans working in the industry were exposed and millions more continue to remain at risk for exposure as asbestos still exists in homes, schools, apartment complexes and dozens of other types of buildings across the country. Individuals who believe they may have been exposed to asbestos particles and fibers should seek medical attention as soon as possible. After receiving a mesothelioma cancer prognosis, it is suggested that a victim speak with an experienced lawyer. Because of the high cost of medical bills associated with this terrifying disease, it is advisable to develop mesothelioma litigation as monetary compensation may potentially be awarded.
Both Nathan Wei & Alan Haburchak are contributors for EditorialToday. The above articles have been edited for relevancy and timeliness. All write-ups, reviews, tips and guides published by EditorialToday.com and its partners or affiliates are for informational purposes only. They should not be used for any legal or any other type of advice. We do not endorse any author, contributor, writer or article posted by our team.
Nathan Wei has sinced written about articles on various topics from Arthritis Pain, Health and Arthritis Signs. Nathan Wei, MD FACP FACR is a board-cerfied rheumatologist. For more info: or. Nathan Wei's top article generates over 550000 views. to your Favourites.
Alan Haburchak has sinced written about articles on various topics from Brain Injury, Business Tax and Brain Injury. For more information on mesothelioma treatments, visit . Here, users can find the latest jury verdicts and news. Also use the LegalView. Alan Haburchak's top article generates over 74000 views. to your Favourites.
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