Just like technology, pharmacology is constantly evolving. There is always the new hot drug on the market. Some save lives, some make life more livable, and some help you shed those unwanted pounds without living at the gym. Here is a look at some of the breakthrough pharmaceutical releases set to make their market debut over the next few years.
Pramlintide - Already available in the U.S. as a diabetes treatment, Pramlintide is being studied by Amylin Pharmaceuticals for its ability to produce a feeling of fullness when eating and reduce weight. A synthetic form of a satiety hormone, research has shown that when it's injected into people's bodies before a meal they eat less, even when given foods they crave. Amylin is also looking at how the drug works in combination with other hormones.
CP404 - CP404 is a calcium channel blocker that works as a nasal spray to block olfactory activity, or our sense of smell, and reduce food intake. Compellis Pharmaceuticals is developing the drug, which has only been tested on mice so far, says Compellis CEO Chris Adams. The company plans to begin human testing this year.
Orlistat (Xenical and alli) - A lipase inhibitor, Orlistat promotes weight loss by preventing the digestion and absorption of some fat from food. Unabsorbed fat is then excreted via the stool. It's available by prescription as Xenical and, since June, as alli, the only FDA-approved over-the-counter weight loss product. Orlistat side effects may include gas with oily spotting and an urgent need to have a bowel movement
CLA - A new meta-analysis by University of Wisconsin at Madison researchers has shown that supplements containing conjugated linoleic acid (CLA), on the market for years, may help people shed fat. It's believed that CLA, a fatty acid found in foods of animal origin such as beef, modifies enzymes responsible for storing and burning fat. Supplements are a good vehicle for CLA because it would be difficult for people to get enough of the fatty acid without loading up on saturated fat.
PP - Researchers at the Imperial College, London, are looking at how gut hormones--pancreatic polypeptide (PP) in particular--affect appetite control. The hormones are released when a person eats, acting as neurotransmitters that tell the brain to stop eating. Though it's being developed in the form of an injection, it's possible in the future that it could be produced as a patch or gum. Researchers hope to start phase one trials early next year and get the drug on the market in three to five years.
Y2R blocker - Georgetown University Medical Center researchers have been able to use nontoxic chemical injections to add and remove fat from lab mice. To add fat, researchers injected the neurotransmitter NPY into the mice. It's believed that NPY is activated during stress, causing apple-shaped obesity and metabolic syndrome. But administration of the receptor Y2R into the mice's abdominal fat prevented both results, melting the fat. Researchers hope that blocking Y2R might work the same way in humans.
Rimonabant (Acomplia) - Approved for use in the European Union as an obesity treatment, rimonabant selectively blocks the CB1 receptors of the endocannabinoid system. This system of receptors in the brain and body helps regulate food intake and how the body uses and stores fats and sugars. In clinical trials, rimonabant has been shown to reduce body weight, with side effects such as nausea and anxiety. Sanofi-aventis withdrew its FDA new drug application for rimonabant last month but is working toward resubmitting.
Suppressing Rip140 - Research has shown that suppression of receptor-interacting protein 140 (Rip140), a nuclear hormone co-repressor that regulates fat accumulation, can accelerate fat burning in animals and fat cells. Initially the subject of experiments at Imperial College in London, RXi Pharmaceuticals is developing the approach as a potential obesity or type-2 diabetes treatment.
Cetilistat - Under development by Alizyme, Cetilistat is a gastrointestinal lipase inhibitor that blocks fat digestion and absorption, causing weight loss. Clinical trials have shown that the drug has fewer side effects than Xenical, according to Alizyme. Cetilistat is currently being prepared for phase-three clinical development.
Meridia - An oral prescription medication, Meridia works by affecting the appetite control center in the brain. Most people who lose weight on the drug, in combination with diet and exercise, do so in the first six months of treatment, according to its maker, Abbott Laboratories. Common side effects include headache, dry mouth, constipation and insomnia.
So, have you scoped out the ones that sound like the next big wonder drug? Well don't get too excited, these need a little more time before they are readily available to the public but keep your eyes peeled for them over the next few years. And remember that being healthy is more than just a weight game. Be active, be fit, be healthy, and you will look good naked. The ultimate goal right?
Copyright (c) 2007 Luke Burgis
The Fat Loss Code
Follow these 10 “laws" of fat loss and you are guaranteed a leaner physique. Think about it; not too many things in life are guaranteed. Often times we have to put a lot of work into something without knowing whether our effort will pay off in the end. This is just part of life, but with fat loss we know we will be successful as long as we have a solid plan in place and as long as we stick to that plan. The sticking to it is usually the part we have the most trouble with. It can be difficult to stay on a fat loss eating plan, but it becomes a little easier when you consistently remind yourself that a leaner you is right around the corner if you just stick with it. You are probably already familiar with some of these laws. If that is the case then now it is just a matter of bringing it all together and DOING IT!
1)You must create a slight calorie deficit in order to lose body fat. The most effective way to do this is to exercise and control the number of calories you ingest each day. Get use to knowing the number of calories that are contained in everything you eat. This is made easy for us with nutrition labels on store bought food and nutritional information sheets available at most fast food restaurants.
2)You must feed your body smaller meals every 2-3 hours throughout the day. Eating this way compared to the normal 3 meals a day increases your metabolic rate significantly. It also prevents you from ever getting too hungry, which is when you are most likely to go off of your nutrition plan and consume too many calories.
3)Every one of your small meals throughout the day should contain a source of high quality protein, carbohydrates, and “good" fat, with the exception of post workout meals, which should consist of fast digesting carbohydrates and proteins and very little or no fat. High quality meal replacements are a great way to supplement several of your meals during the day.
4)Drink enough water every single day. Having adequate water enables your body to function properly, including its ability to burn fat. Water also flushes toxins and impurities from the body.
5)Always incorporate weight training and cardiovascular exercise into your fat loss nutrition plan.
6)Use the power of vegetables to help you reach your goals. Vegetables are the most nutrient dense food around meaning that you can eat a tremendous quantity of vegetables and consume very few calories. The high fiber content of vegetables also causes your body to work very hard just to digest the vegetables, which means that the calories you do consume are all burned up just in the digestion process. So, in turn, vegetables are negative calories! If you get hungry you can always add more vegetables with no fear of hurting your fat loss efforts (Fried okra does not count!)
7) Pick a nutrition plan that you can live with and that you have faith in. If you cannot consistently follow a nutritional program then you will never have success with it. A good rule to remember is that any “diet" that you eventually come off of will fail in the long run. To have success you must incorporate a nutritional program that you can follow for the rest of your life. This requires a lifestyle change and commitment on your part. It is also important that you have faith and confidence in your fat loss nutrition program. If you do not truly believe that something is going to work for you, then you will not stick with it.
8)“Cheat" if you want to, but know the consequences of excessive overindulgence. Having a “cheat" day or cheat meal every week or every two week, in which you allow yourself to eat whatever food you are craving, is a great way to help you stick with your nutritional program. “Cheat" days give us a mental break and allow us to enjoy some of our favorite foods so that we do not feel deprived. However, don’t fool yourself into thinking that your body “needs" these cheat days, and be careful of the quantity of food you eat on your cheat day. If your cheat meal turns into a full day of pigging-out on everything in sight then you can easily undo all of the hard work you put in the week before.
9)Keep your eye on the prize. Eating to lose body fat is tough. I am not going to lie and say it isn’t. There will undoubtedly be times when you feel like giving up and accepting the fact that you can never achieve your ideal physique and level of health and fitness. When you feel like this take a couple of minutes to remind yourself exactly why you are doing it. Think of how awesome it is going to feel when you finally do reach your goals. Trust me, when you achieve your fat loss goals and reach a new level of health and fitness, it will be well-worth the sacrifice you had to make along the way.
10)Be consistent and never give up. Permanent fat loss requires a lifelong commitment to eating healthier and exercising. Don’t become frustrated or give up if you do not seem to be reaching your goals as quickly as you would like. Achieving the body and level of fitness you desire takes time and consistency. If you mess up on your nutrition plan don’t beat yourself up. Instead, get right back to it and keep making progress because with enough determination and desire you WILL eventually get there.
Both Luke Burgis & Russ Yeager Yeager are contributors for EditorialToday. The above articles have been edited for relevancy and timeliness. All write-ups, reviews, tips and guides published by EditorialToday.com and its partners or affiliates are for informational purposes only. They should not be used for any legal or any other type of advice. We do not endorse any author, contributor, writer or article posted by our team.
Luke Burgis has sinced written about articles on various topics from Vitamin B Complex, Health and Fat Loss. This article is from the online marketing director of Fit Fuel, Amber Thompson. Fit Fuel is a leading natural and organic foods retailer on the web (
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