The U.S. Food and Drug Administration (FDA) has approved Wellbutrin XL(R) for the prevention of seasonal major depressive episodes in patients with a diagnosis of seasonal affective disorder (SAD), a condition affecting about 6 percent of American adults. Wellbutrin XL is the first and only medication approved to prevent seasonal major depressive episodes.



"Seasonal affective disorder is a serious and often under-diagnosed form of depression that affects millions of people each year in the United States," said Norman E. Rosenthal, M.D., clinical professor of Psychiatry at Georgetown Medical School and medical director of Capital Clinical Research Associates. "The FDA approval of Wellbutrin XL for the prevention of seasonal major depressive episodes in adults diagnosed with SAD is exciting. For the first time, it may be possible to prevent the predictable onset of SAD with medication by beginning treatment in the autumn season, prior to experiencing depressive symptoms."

A combined analysis of three clinical trials showed that Wellbutrin XL reduces the chance of developing a seasonal major depressive episode by 44 percent.

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